Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000100
Title: Synthesis and in-vitro antimalarial evaluation of Pyrazoline: A new antimalarial scaffold
Category: Pharmaceutical Chemistry
Section: Research Article
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    Aim: Synthesis of novel Imino-arylidene derivatives of Pyrazoline and evaluation of their in-vitro antimalarial activity. Method: It involved three steps. Initially 1-(4-aminophenyl)-3-arylprop-2-en-1-ones (1a-1f) were synthesized by Claisen-Schmidt condensation. Further, compounds (1a-1f) were refluxed with hydrazine hydrate using ethanol as solvent, to yield pyrazoline derivatives (2a-2f). Compounds (2a-2f) on refluxing with 4-methoxy benzaldeyde yield title compounds 1-(4-methoxyphenyl)-N-[4-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)phenyl]methanimine (3a-3f). The synthesized compounds were characterized by using IR, NMR and Mass spectral data. Compounds were evaluated for their in-vitro antimalarial activity against 3D7 P. falciparum using chloroquine as standard drug. Result: Imino-arylidene derivatives of Pyrazoline (3a-3f) exhibited better in vitro antimalarial activity against 3D7 P. falciparum as compared to pyrazolines (2a-2f). Compound 3d was found to have IC50 value of 9.99µgmL-1. Conclusion: An increase in number of methoxy group on Imino-arylidene derivatives of Pyrazoline results in an increase in in-vitro antimalarial activity.

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    Author(s) Name:

    Akranth Marella, Mymoona Akhter, Mohammad Shaquiquzzaman, Asif Husain, Wasim Akhter, Garima Verma, Mohammad Mumtaz Alam*

    Affiliation(s) Name:

    Department of Pharmaceutical Chemistry,Faculty of Pharmacy,Jamia Hamdard,New Delhi 110062, India

    *Corresponding author.
    Mohammad Mumtaz Alam
    Department of Pharmaceutical Chemistry
    Faculty of Pharmacy
    Jamia Hamdard,
    New Delhi 110062, India
    E-mail: drmmalam@gmail.com

    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:06-01-2014

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    Author:

    Akranth Marella, Mymoona Akhter, Mohammad Shaquiquzzaman, Asif Husain, Wasim Akhter, Garima Verma, Mohammad Mumtaz Alam*

    Title:Synthesis and in-vitro antimalarial evaluation of Pyrazoline: A new antimalarial scaffold
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (January )
    Year:2014
    Page No: (77-80)
  • Experimental Methods Keywords

    Methodology:Claisen-Schmidt condensation, IR, NMR and Mass spectral data,antimalarial activity
    Research Materials:Pyrazoline

Keywords

Pyrazoline Schiff base Antimalarial

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