Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001001
Title: Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
Category: Pharmacology
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    Purpose: Vinpocetine is a phosphodiesterase type-1 inhibitor having strong vasodilating effect through cAMP and cGMP elevation. Vasodilators may play positive role in myocardial infarction (MI). As vinpocetine has not been explored for its cardioprotective role so far, we proposed to investigate the same in experimental model. Wistar albino rats were randomly divided into control, isoproterenol (85 mg/kg, s.c. on 6th & 7th day), vinpocetine (10 mg/kg/day, p.o.), milrinone (4 mg/kg/day, p.o.), vinpocetine + isoproterenol and milrinone + isoproterenol groups. On 8th day lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), total antioxidant capacity (TAC) in serum and reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), Na+/K+ ATPase (NKA) in myocardium were estimated. Results: Isoproterenol-induced MI manifested a significant (P < 0.001) increase in the LDH, CK-MB, NKA, TBARS and a substantial decrease in GSH & TAC levels (P < 0.001 & P < 0.05, respectively). These levels were significantly reverted towards normal on treatment with vinpocetine and milrinone. Per se groups of these drugs however, did not show any significant changes when compared with the control. Histopathological evaluation also revealed the same trend. Conclusion:Biochemical and histopathological parameters clearly indicate the cardioprotective potential of vinpocetine due to its antioxidative and myocardial membrane stabilizing effects.

    Cite this article as: Mohammed Kaleem and Syed Ehtaishamul Haque,Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats, Journal of Pharmacy Research 2015,9(7),408-414

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    Author(s) Name:

    Mohammed Kaleem and Syed Ehtaishamul Haque*

    Affiliation(s) Name:

    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India

    *Corresponding author.
    Dr. Syed Ehtaishamul Haque
    Department of Pharmacology,
    Faculty of Pharmacy,
    Jamia Hamdard, New Delhi 11 0062, India

    Received on:23-06-2015; Revised on:15-07-2015 ; Accepted on: 02-08-2015

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    Author:

    Mohammed Kaleem and Syed Ehtaishamul Haque*

    Title:Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
    Journal:Journal of Pharmacy Research
    Vol(issue):9(7)
    Year:2015
    Page No: (408-414)
  • Experimental Methods Keywords

    Methodology:Cardioprotective activity, membrane-stabilization, phosphodiesterase inhibitors.
    Research Materials:Vinpocetine

Keywords

Cardiac toxicity antioxidant membrane-stabilization phosphodiesterase inhibitors.

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