Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00001014
Title: Antimicrobial and Anticancer Studies on Euphorbia heterophylla
Category: Microbiology
Section: Research Article
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    Euphorbia heterophylla is a local medicinal plant used in ethno medicine for the treatment of constipation, bronchitis and asthma. E. heterophylla is medicinal plant with the common name “spurge weed”. In the present study selected plant drug was screened for its anticancer activity by Invitro and Insilco methods. Preliminary phytochemical screening revealed the presence of Terpenoids, Quinones, Alkaloids, Sterol, Coumarin, Starch, and Protein. Ethanol extract was tested for their antibacterial property against various organisms. The extract showed significant antimicrobial activity particularly in Proteus vulgaris and Staphylococcus aureus. Alcoholic extract of plant material showed significant in-vitro cytotoxic activity on EAC (Ehrlich ascites carcinoma) cell lines. GC-MS was carried out in ethanol extract of Euphorbia heterophylla.31 compounds were identified. Bioinformatics tools were employed in understanding the mechanism of action. 14 of the compounds were docked with the Bcl-2 protein, among them Allantoic acid was considered as best candidate as it is having least energy in docking.

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    Author(s) Name:

    M.Meenakshi Sundaram*, K.Karthikeyan@ D.Sudarsanam# and P.Brindha*

    Affiliation(s) Name:

    *School of Chemical & Biotechnology, SASTRA University, Thanjavur – 613401. TamilNadu, INDIA.
    @Department of Biotechnology, Srimad Andavan Arts and Science College, Tiruchirapalli-620005, TamilNadu, INDIA.
    #Dept of Adv. Zoology & Biotechnology, Loyola College, Nungambakkam, Chennai-34. TamilNadu, INDIA.

    *Corresponding author.
    M.Meenakshi Sundaram
    Asst.Professor
    School of Chemical & Biotechnology
    Sastra University
    Thanjavur – 613401.Tamilnadu, INDIA.


    Received on: 15-04-2010; Revised on: 18-05-2010; Accepted on:13-07-2010

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    Author:

    M.Meenakshi Sundaram*, K.Karthikeyan@ D.Sudarsanam# and P.Brindha*

    Title:Antimicrobial and Anticancer Studies on Euphorbia heterophylla
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (September)
    Year:2010
    Page No: (2332-2333)
  • Experimental Methods Keywords

    Methodology:Antimicrobial and Anticancer Studies
    Research Materials:Euphorbia heterophylla

Keywords

Ehrlich ascites carcinoma Docking studies Bcl-2

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