Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000104
Title: Synthesis and molecular docking studies of few novel Pyrimidine derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    This study was designed to synthesize some novel pyrimidine derivatives by using chalcone and thiourea. 10 different compounds thus formed were further reacted with ethylchloroacetate and then with hydrazine hydrochloride. The synthesized pyrimidinethioester hydrazide were subjected to docking studies against protein Human Cyclin Dependent Kinase 2 Complexed with the CDK4 Inhibitor (1GII) using Argus Lab software. The result indicates that the synthesized derivatives shows ligand bind pose energy varies from -8.35388 kcal/mol to -10.7195 kcal/mol. Of the 10 compounds, compound IV shows ligand bind pose energy -10.0084 kcal/mol with 4 hydrogen bond having best anticancer activity. This study also suggested that all the synthesized pyrimidine derivatives show potent anticancer activity than the standard drug 6-mercaptopurine.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Sonia D. Arikkatt*, Meena Chandran, A.R Bhat, K Krishnakumar 

    Affiliation(s) Name:


    Department of Pharmaceutical Chemistry, St. James College of Pharmaceutical Sciences, Chalakudy-680307, Kerala,India.

     

    *Corresponding author.
    Sonia D. Arikkatt
    Department of Pharmaceutical Chemistry,
    St. James College of Pharmaceutical Sciences,
    Chalakudy-680307, Kerala,India.
    E-mail: soniadarikkatt@gmail.com


    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:12-01-2014

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Sonia D. Arikkatt*, Meena Chandran, A.R Bhat, K Krishnakumar 

    Title:Synthesis and molecular docking studies of few novel Pyrimidine derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (93-97)
  • Experimental Methods Keywords

    Methodology:Molecular docking studies
    Research Materials:Pyrimidine derivatives

Keywords

Pyrimidine 6-mercaptopurine 1GII Argus Lab.

Our Services

Most Downloaded List