Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001044
Title: Synthesis and antioxidant activity of novel ketone hydrazones bearing 5-(Pyridine-3-yl)-1,3,4-thiadiazole
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    A new series of Ketone 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)-hydrazone derivatives (4a-h) were synthesized in good yield by the condensation of 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazine with substituted and unsubstituted ketones and evaluated their antioxidant property by using 1,1-diphenyl-2-picryl-hydrazil (DPPH.) method. All the compounds showed good antioxidant activity.

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    Author(s) Name:

    K. Jagadeesh Prathapa, M. Himajaa*, Sunil V. Malib, Anand Ranjithaa, Asif Karigarc, Mukesh Sikarward

    Affiliation(s) Name:

    aSchool of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.
    bMedicinal Chemistry Division, Piramal Life Sciences, Nirlon Complex, Goregaon East, Mumbai -400 063, India.
    cMaratha Mandal College, Belgaum, Karnataka, India
    dKLE College of Pharmacy, Ankola, Karnataka, India

    *Corresponding author.

    Dr. (Mrs). M. Himaja,
    Professor, School of Advanced Sciences
    VIT University, Vellore – 632014
    Tamil Nadu, India.
    Received on: 15-06-2010; Revised on: 18-08-2010; Accepted on:13-09-2010

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    Author:

    K. Jagadeesh Prathapa, M. Himajaa*, Sunil V. Malib, Anand Ranjithaa, Asif Karigarc, Mukesh Sikarward

    Title:Synthesis and antioxidant activity of novel ketone hydrazones bearing 5-(Pyridine-3-yl)-1,3,4-thiadiazole
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (October)
    Year:2010
    Page No: (2460-2462)
  • Experimental Methods Keywords

    Methodology:Synthesis and antioxidant activity
    Research Materials:1,3,4-Thiadiazole

Keywords

1 3 4-Thiadiazole Ketone-Hydrazones Antioxidant activity.

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