Journal: Journal of Pharmacy Research

Article Id: JPRS-PDD-0000105
Title: Synthesis and characterization of biocompatible gold nanoparticles stabilized with hydrophilic polymer coated hesperetin drug for sustained drug delivery to treat hepatocellular carcinoma-derived ca
Category: Process Development of Drugs
Section: Research Article
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    The biological application of polymer coated gold nanoparticles in the recent chemotherapeutic work on drug delivery as a carrier has been effective for the treatment of cancer. Obviously in the production of pharmaceutical anticancer drugs, the factors like solubility, bioavailability, biocompatibility, limited chemical stability etc., are necessary with a special formulation technology in effective drug delivery. Our aim of the present study was to improve the solubility of the drug and reduce the side effects of chemotherapy drugs. Therefore, we report a simple and efficient method to synthesize a biocompatible nano carrier (polymer functionalized gold nanoparticles) to load the partially soluble drug (Hesperetin). Initially the carrier viz., the polymer functionalized gold nanoparticles (Au- mPEG (5000)-SH) was synthesized by reacting the tetrachloroauric acid (HAuCl4) with polymer (O-[2-(3-Mercaptopropionylamino) ethyl]-O’-methylpolyethylene glycol). Then, the anti-liver cancer drug viz., hesperetin (HP) was loaded on to the Au- mPEG (5000)-SH to treat the hepatocellular carcinoma. The formation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized using UV-VIS spectrophotometer, HR-TEM with EDAX, and DLS with Zeta potential techniques. The in vitro drug release was carried out in PBS at pH 7.4 for Au- mPEG (5000)-S-HP and compared with the control pure hesperetin (HP). The in vitro cytotoxicity was studied using Hep3B human hepatocellular carcinoma cell line and observed that the cellular uptake of Au- mPEG (5000)-S-HP was higher when compare with pure drug (HP). These consistent results suggest that mPEG (5000)-S-HP functionalized Au nanoparticles could be used as an efficient drug for in vivo to treat hepatocellular carcinoma in animals.

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    Author(s) Name:

    Krishnan Gokuladhas, Subramaniyan Jayakumar , Arumugam Madankumar,
    Balan Rajan, Ramasamy Elamaran, Subramani Pramila and Thiruvengadam Devaki*

    Affiliation(s) Name:

    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India.

    *Corresponding author.
    Thiruvengadam Devaki
    Department of Biochemistry,
    University of Madras,
    Guindy Campus,
    Chennai 600 025, Tamilnadu, India.
    E- mail: gokul_bt@yahoo.com


    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:11-01-2014

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    Author:

    Krishnan Gokuladhas, Subramaniyan Jayakumar , Arumugam Madankumar,
    Balan Rajan, Ramasamy Elamaran, Subramani Pramila and Thiruvengadam Devaki*

    Title:Synthesis and characterization of biocompatible gold nanoparticles stabilized with hydrophilic polymer coated hesperetin drug for sustained drug delivery to treat hepatocellular carcinoma-derived ca
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (98-105)
  • Experimental Methods Keywords

    Methodology:Synthesis of gold mediated polymer coated drug, In vitro drug release study,Cellular uptake and cytotoxicity studies
    Research Materials:Hesperetin

Keywords

Gold nanoparticles Hesperetin Drug delivery Cytotoxicity.

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