Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001051
Title: Enhancement of dissolution rate of Efavirenz by solid dispersion technique
Category: Pharmaceutics
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  • Abstract

    Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, solid dispersion method is designed and evaluated. Solid dispersions of Efavirenz were prepared using PEG 6000. The effect of fusion-solvent methods of preparation of solid dispersion on dissolution behavior was also investigated. Dissolution studies indicated a significant increase in dissolution of Efavirenz when dispersed in PEG6000. Solid dispersions containing Efavirenz / PEG 6000, 1: 8, showed a 2-fold increase in dissolution after 180 min in the 0.1 N HCL systems.

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    Author(s) Name:

    Bada Pragati Kumar*, Mohammad Yunoos, Nala Chandana, Mohammad Habeeb and B.Himaja

    Affiliation(s) Name:

    *Department of Pharmaceutics,Nimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada-521456.

    *Corresponding author.
    Bada Pragati Kumar
    Department of Pharmaceutics,Nimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada-521456


    Received on: 15-06-2010; Revised on: 18-08-2010; Accepted on:13-09-2010

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    Author:

    Bada Pragati Kumar*, Mohammad Yunoos, Nala Chandana, Mohammad Habeeb and B.Himaja

    Title:Enhancement of dissolution rate of Efavirenz by solid dispersion technique
    Journal:Journal of Pharmacy Research
    Vol(issue):3(12)
    Year:2010
    Page No: (2840-2842)
  • Experimental Methods Keywords

    Methodology:Enhancement of dissolution rate
    Research Materials:Efavirenz

Keywords

Efavirenz PEG 6000 Solid dispersion Enhancement in dissolution.

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