Journal: Journal of Pharmacy Research
Title: Dissolution enhancement of Paracetamol by solid dispersion technique
Category: Pharmaceutics
Section: Research Article
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Abstract
Paracetamol is a potent anti-inflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylytis. Paracetamol is poorly water soluble and may show dissolution limited absorption. The solid dispersion of paracetamol by physical triturating method, and fusion method were prepared using 1:1,1:4 and 1:5 ratios of drug and polymers (PEG 4000, PEG 6000 and urea). The solid dispersion (SD) was characterized for physical appearance, solubility, IR, and in vitro dissolution studies. FTIR study revealed that drug was stable in SDs. Solubility of paracetamol from SDs increased in distilled water. The drug content was found to be high and uniformly distributed in the all formulation. The in vitro dissolution studies were carried using USP type XXVII (paddle) type dissolution apparatus. The prepared dispersion showed marked increase in the dissolution rate of paracetamol than that of pure drug. The dispersion with PEG 6000 (1:5) by fusion method showed faster dissolution rate (107.26%) as compared to other dispersions with PEG 4000 and urea (1:4 and 1:5) whichever prepared by physical mixture (PM) and fusion method). Of the three carriers used, dissolution of the drug was more in PEG 6000 based SDs. It is concluded that dissolution of the Paracetamol could be improved by the solid dispersion and PEG6000 based solid dispersions were more effective in enhancing the dissolution.
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About the authors and Affiliations
Author(s) Name: D. Akiladevi *1, Sachinandan Basak2
Affiliation(s) Name: *1 Department of Pharmaceutical Sciences, Mohamed Sathak A.J College of Pharmacy, Sholinganallur, Chennai-600119,
2Dr.Reddy’s Laboratories Ltd, Bachupalli, Qutubullapur, RR district 500090, Andhrapradesh.*Corresponding author.
D. Akiladevi
Department of Pharmaceutical Sciences,
Mohamed Sathak A.J College of Pharmacy,
Sholinganallur,
Chennai-600119.
Received on: 12-08-2010; Revised on: 06-10-2010; Accepted on:08-11-2010-
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Author: D. Akiladevi *1, Sachinandan Basak2
Title: Dissolution enhancement of Paracetamol by solid dispersion technique Journal: Journal of Pharmacy Research Vol(issue): 3 (December) Year: 2010 Page No: (2846-2849) -
Experimental Methods Keywords
Methodology: Dissolution enhancement Research Materials: Paracetamol
Keywords
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