Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001053
Title: Effect of Punica granatum fruits in inflammatory bowel disease
Category: Pharmacology
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    It has been demonstrated that Punica granatum Linn. (Punicaceae) is useful as an adjunctive therapy for inflammatory bowel disease. However, its effect on ulcerative colitis has not been investigated. In the present study, Punica granatum was tested for 2, 4 - dinitro benzene sulfonic acid (DNBS) induced colitis, and antioxidant activity was evaluated to clarify its possible mode of action. Male albino wistar rats were randomly divided into five groups: Normal control (Group I), vehical contol (Group II), colitis induced by DNBS without any therapy (Group III), colitis treated with standard 5-Amino salicylic acid (Group IV), colitis treated with test drug punica granatum (Group V). Treatment was given for 18 days. Rats were sacrificed on the 18th day after the procedure. Malondialdehyde (MDA), Nitric oxide (NO), Myeloperoxidase (MPO), Superoxide dismutase (SOD), activity were measured in the isolated colon tissue. MDA, NO, MPO levels in colon tissue homogenate were decreased & SOD level was increased in group IV & Group V as compare to those of Group III. There was also increase in food intake, water intake, % body weight & decreased colon weight in Group IV & Group V as compared to Group III. There was also improvement in inflammatory indices of colon mucosal damage index (CMDI) & Disease activity index (DAI) & histopathology of Group IV & Group V as compared to those of group III. The results of our study suggest that Punica granatum therapy has beneficial effects on the course of experimental colitis.

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    Author(s) Name:

    Darji V.C 1*, Bariya A.H2, Deshpande S.S3, Patel D.A4

    Affiliation(s) Name:

    1Department of Pharmacology, Sharda School of Pharmacy, Pethapur-Mahudi road, pethapur Gandhinagar-382610, Gujarat, India.
    2Department of Pharmacology, Kalol Institute of Pharmacy, Opposite to Janpath hotel, Kalol-382721, Gujatat, India.
    3Department of Pharmacology, K.B. Institute of Pharmaceutical Education & Research, Sector-23, Gandhinagar-382023, Gujarat, India.
    4Department of Pharmacognosy, Arihant College of Pharmacy, S.G. Highway, Uavarsad, Gandhinagar-382422, Gujarat, India.

    *Corresponding author.
    Vinay Darji,
    Department of Pharmacology,
    Sharda School of Pharmacy, Pethapur,
    Gandhinagar-382610, Gujarat, India.


    Received on: 10-08-2010; Revised on: 18-10-2010; Accepted on:20-11-2010

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    Author:

    Darji V.C 1*, Bariya A.H2, Deshpande S.S3, Patel D.A4

    Title:Effect of Punica granatum fruits in inflammatory bowel disease
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (December)
    Year:2010
    Page No: (2850-2852)
  • Experimental Methods Keywords

    Methodology:Inflammatory bowel disease (IBD), Antioxidant
    Research Materials:Punica granatum Linn. (Punicaceae)

Keywords

Punica granatum Linn. (Punicaceae) Inflammatory bowel disease (IBD) Antioxidant

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