Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001055
Title: Antioxidant and Healing Effect of Aqueous alcoholic Extract of Rhodomyrtus tomentosa (Ait.) Hassk on Chronic Gastric Ulcers in rats
Category: Pharmacology
Section: Research Article
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  • Abstract

    Rhodomyrtus tomentosa is a medicinal plant used traditionally in gastric disorders like colic, diarrhoea, dysentery, abscesses, haemorrhage, and as an antiseptic wash for wounds. Based on the ethnomedical information of the plant, the antiulcerogenic activity of an aqueous alcoholic (70%) extract of Rhodomyrtus tomentosa was investigated using acetic acid-induced chronic ulcer model in rats. The reduction in ulcer index followed by increase in the levels of superoxide dismutase (SOD) and catalase (CAT) and decrease in lipid peroxidation proved the antiulcer and antioxidant activity of the extract. Histopathological studies further proved the gastroprotective property of the extract. It was concluded that the extract possesses significant anti-ulcer activity, which can be attributed to its antioxidant mechanism of action. The presence of triterpenoids, flavonoids and phenolic compounds is probably related to the potent antiulcerogenic and antioxidant activity.

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    Author(s) Name:

    Geetha KM*1., Sridhar C2 and Murugan V1.

    Affiliation(s) Name:

    1Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India.
    2C.E.S. College of Pharmacy, Kurnool, Andhra Pradesh, India

    *Corresponding author.
    Geetha KM*
    1Department of Pharmacology,
    Dayananda Sagar College of Pharmacy, Bangalore, India.


    Received on: 20-08-2010; Revised on: 16-09-2010; Accepted on:19-11-2010

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    Author:

    Geetha KM*1., Sridhar C2 and Murugan V1.

    Title:Antioxidant and Healing Effect of Aqueous alcoholic Extract of Rhodomyrtus tomentosa (Ait.) Hassk on Chronic Gastric Ulcers in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (December)
    Year:2010
    Page No: (2860-2862)
  • Experimental Methods Keywords

    Methodology: antiulcer, antioxidant activity
    Research Materials:Rhodomyrtus tomentosa

Keywords

Rhodomyrtus tomentosa Acetic acid antiulcer antioxidant activity.

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