Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001066
Title: Solubility enhancement of nevirapine by cocrystallisation technique
Category: Pharmaceutics
Section: Research Article
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    The objective of present study was to enhance solubility of Nevirapine by cocrystallisation technique.Nevirapine is non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretroviral and having poor aqueous solubility and dissolution profile. The method used for co-crystal formation was neat grinding method. The co-crystals were prepared by using conformer Maleic acid. The method used for co-crystal formation was neat grinding method. Further prepared co-crystals were characterized by Powder X-ray diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transformation Infra-red Spectroscopy (FTIR). Moreover they were studied for melting point determination, flow property studies and dissolution studies. All the performed study revealed formation of co-crystals, improvement in micromeritic properties and dissolution behavior of drug. The result shows that solubility of Nevirapine was improved by 106 folds via crystal engineering technique.

    Cite this article as: Yogesh K. Nalte, Vilas A. Arsul, Santosh G. Shep, DR. Sunil B. Bothara,Solubility enhancement of nevirapine by cocrystallisation technique,Journal of Pharmacy Research 2015,9(8),556-561

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    Author(s) Name:

    Yogesh K. Nalte*, Vilas A. Arsul, Santosh G. Shep, DR. Sunil B. Bothara

    Affiliation(s) Name:

    Shri Bhagwan College of Pharmacy, Department of Quality Assurance, Aurangabad-431 003, India.

    *Corresponding author.
    Yogesh Nalte,
    ShriBhagwan College of Pharmacy,
    Aurangabad -431 003, India


    Received on:22-06-2015; Revised on: 25-07-2015; Accepted on: 21-08-2015

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    Author:

    Yogesh K. Nalte*, Vilas A. Arsul, Santosh G. Shep, DR. Sunil B. Bothara

    Title:Solubility enhancement of nevirapine by cocrystallisation technique
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (August)
    Year:2015
    Page No: (556-561)
  • Experimental Methods Keywords

    Methodology:Co-crystallization, dissolution behavior, micromeritic properties
    Research Materials:Nevirapine

Keywords

Co-crystallization dissolution behavior micromeritic properties Nevirapine.

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