Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001067
Title: Effect of Process Variables on the Size Distribution of Aluminium Chloride Cross-linked Sodium Alginate Microspheres
Category: Pharmaceutics
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    In the present study, spherical microspheres of diclofenac sodium using sodium alginate as the hydrophilic carrier and aluminium chloride as a cross-linker were prepared. The shape, surface and size characteristics were determined by binocular microscopy. The microspheres were found to be discreet and spherical in shape. Results of rheological study of polymer solutions showed the increase in viscosity with the increase in polymer concentration and increase in concentration of cross-linker (from 20.77 cP to 1283 cP and from 580.42 cP to 4800.82 cP, respectively). Micromeritic properties of microspheres were studied. It was observed that mean particle size of the microspheres increased from 81.76 ± 5.21 µm to 185.7 ± 2.47 µm and 57.46 ± 4.91 µm to 223.5 ± 5.71 µm with an increase in the concentration of polymer and drug:polymer ratio respectively. The increase in cross-linker concentration and stirring rate gave decrease in mean particle size of the microspheres from 165.7 ± 3.17 µm to 125.9 ± 4.78 µm and 290.5 ± 6.32 µm to 52.16 ± 7.39 µm, respectively. The desired size of microspheres can be obtained by using these process variables. Further these findings help the industry to scale up the commercial production.

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    Author(s) Name:

    Jitendra Kawadkar 1*, Meenakshi K. Chauhan 1, and Maheshwari Maharana 2

    Affiliation(s) Name:

    1 Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi, New Delhi, 110017, India.
    2 Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201303, India.

    *Corresponding author.
    Jitendra Kawadkar
    Delhi Institute of Pharmaceutical
    Sciences and Research (DIPSAR),
    University of Delhi,
    New Delhi, 110017, India.


    Received on: 19-07-2010; Revised on: 16-10-2010; Accepted on:05-11-2010

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    Author:

    Jitendra Kawadkar 1*, Meenakshi K. Chauhan 1, and Maheshwari Maharana 2

    Title:Effect of Process Variables on the Size Distribution of Aluminium Chloride Cross-linked Sodium Alginate Microspheres
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (December)
    Year:2010
    Page No: (2879-2883)
  • Experimental Methods Keywords

    Methodology:Effect of Process Variables on the Size Distribution
    Research Materials:Sodium alginate

Keywords

Sodium alginate microspheres aluminium chloride size distribution

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