Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001068
Title: Simultaneous estimation of rizatriptan, sumatriptan and zolmitriptan by RP-HPLC method in bulk
Category: Pharmaceutics
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    A simple reverse phase HPLC method was developed for the simultaneous estimation of Rizatriptan, Sumatriptan and Zolmitriptan in bulk form. Chromatography was performed by gradient reverse phase separation on a Stainless steel column 4.6 x 250mm, symmetry column packed with octa decyl silane bonded to porous silica (C18) with particle size 5 micron with mobile phase Acetonitrile: Sodium Phosphate buffer. The flow rate was 1.0ml/ min and effluent was monitored at 280 nm. The retention times were 7.215min, 8.432 and 9.185min for of Rizatriptan, Sumatriptan and Zolmitriptan respectively. The standard curve was linear over a working range of 1–10 µg/ml and gave an average correlation coefficient of 0.9996, 0.9992, and 0.9992 for Rizatriptan, Sumatriptan and Zolmitriptan respectively. The limit of quantitation (LOQ) of this method was 2µg/ml for rizatriptan Sumatriptan and Zolmitriptan. The absolute recovery was 101.84 for rizatriptan, 101.492 for sumatriptan and 101.44 for zolmitriptan. This method can be easily and conveniently adopted for routine analysis of Rizatriptan, Sumatriptan and Zolmitriptan in pure form and can also be used for dissolution or similar studies.

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    Author(s) Name:

    * P. Vivek Sagar1, Dhiraj Kumar2, Suddhasattya Dey2 and Himansu Bhusan Samal2

    Affiliation(s) Name:

    1Royal College of Pharmacy and Health Sciences, Gangam Dist. Berhampur-760002. (Orissa)
    2Guru Nanak Institute of Pharmacy, Ibrahampatnam, R.R. Dist. Hyderabad-501506. (A.P.)

    *Corresponding author.
    P. Vivek Sagar
    Royal College of Pharmacy and Health Sciences,
    Gangam Dist. Berhampur-760002. (Orissa) 


    Received on: 15-07-2010; Revised on: 18-09-2010; Accepted on:13-11-2010

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    Author:

    * P. Vivek Sagar1, Dhiraj Kumar2, Suddhasattya Dey2 and Himansu Bhusan Samal2

    Title:Simultaneous estimation of rizatriptan, sumatriptan and zolmitriptan by RP-HPLC method in bulk
    Journal:Journal of Pharmacy Research
    Vol(issue):3 (December)
    Year:2010
    Page No: (2930-2933)
  • Experimental Methods Keywords

    Methodology:RP-HPLC method, Simultaneous estimation
    Research Materials:Rizatriptan, Sumatriptan, Zolmitriptan

Keywords

Rizatriptan Sumatriptan Zolmitriptan Chromatography Acetonitrile Sodium Phosphate Buffer.

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