Journal: Drug Invention Today

Article Id: JPRS-MSNS-00001086
Title: Mitochondrial DNA and Inherited Diseases – A Comprehensive Review
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Review Article
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    Mitochondria are membrane-bound organelles located in the cytoplasm of the cell. They are the sites of cellular respiration which ultimately generates fuel for the cell's activities. Mitochondria are the only non-nuclear constituents of the cell with their own DNA (mtDNA) and machinery for synthesizing RNA and proteins. Mutations in the mitochondrial genome have been implicated with a wide range of age-related pathologies, cancers, neurodegenerative diseases and in general, processes that regulate cellular and organismal aging. There has been considerable progress in understanding the role of mtDNA mutations in human diseases during the last two decades, but important mechanisms in mitochondrial genetics remain to be explained at the molecular level. This review gives an overview of mitochondrial DNA structure and function and then outlines more specifically the metabolic and molecular alterations in mitochondria, associated with human diseases and their clinical implications.

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    Author(s) Name:

    Geetha RV1* , Anitha Roy2 , Vishnu PriyaV 3 , Lakshmi T2

    Affiliation(s) Name:

    1Faculty of Microbiology, Saveetha Dental College, Velappanchavady, Chennai-77
    2Faculty of Pharmacology, Saveetha Dental College, Velappanchavady, Chennai-77
    3Faculty of Bio chemistry, Saveetha Dental College, Velappanchavady, Chennai-77

    Corresponding Author:
    Geetha RV, Faculty of Microbiology, Saveetha Dental College, Velappanchavady, Chennai-77


    Received 21-08-2011; Accepted 29-08-2011

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    Author:

    Geetha RV1* , Anitha Roy2 , Vishnu PriyaV 3 , Lakshmi T2

    Title:Mitochondrial DNA and Inherited Diseases – A Comprehensive Review
    Journal:Drug Invention Today
    Vol(issue):3 (September)
    Year:2011
    Page No: (221-226)
  • Experimental Methods Keywords

    Methodology:Somatic Mutations, Endosymbiotic Theory, Ageing, Neurodegenerative Disorders, Myopathies
    Research Materials:Mitochondrial DNA,

Keywords

Mitochondrial DNA Somatic Mutations Endosymbiotic Theory Ageing Neurodegenerative Disorders Myopathies

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