Journal: Journal of Pharmacy Research

Article Id: JPRS-PTD-0000109
Title: Design and Development of chronopharmaceutical Drug Delivery of Lansoprazole
Category: Pharmaceutical Technology Development
Section: Research Article
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    The aim of the present investigation is to develop a pulsatile drug delivery system basedon an insoluble capsule body filled with Lansoprazole matrix tablet and sealed with HPMC K 100 plug. The Lansoprazole matrix tablets were prepared by wet granulation method. The plugs of varying thickness and hardness were prepared by direct compression which was then placed in the capsule opening. The drug delivery system was designed to deliver the drug at such a time when it was needed (nocturnal time). Dissolution studies of pulsatile capsule device in media with different pH (1.2, 7.4 and6.8) showed that drug release in colon could be modulated by optimizing the concentration of polymers in the plug and also the position of plug. The study showed that, lag time prior to drugrelease was highly affected by the plug position. The dissolution data revealed that the plug position and the composition of plug were very important to achieve a optimum formulation. Drug–polymer interaction studies indicated no interaction or complexation in between the drug and the polymer.

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    Author(s) Name:

    Y.Indira Muzib1,P. Jitendra kumar 2,V. Sai Kishore *3, M. Sandeep3, M.Suresh Babu4,P.Mallikharjuna rao5

    Affiliation(s) Name:

    1.Institute of Pharmaceutical Technology,Sri Padmavati Mahila Visvavidyalayam, Tirupati 517501, Andhra Pradesh, India
    2. School of Pharmaceutical Education and Research,Berhampur university,Berhampur 760002,Odisha,India
    3. Bapatla College of Pharmacy, Bapatla, 522101,Guntur,Andhra Pradesh,India
    4.Deccan School of Pharmacy,Dar-us-salam, Aghapura, Hyderabad – 500 001,India
    5.Nalanda Institute of Pharmaceutical Sciences,Kantepudi,Satteanpalli 522403,Guntur, AndhraPradesh, India

    *Corresponding author.
    V. Saikishore
    Bapatla college of pharmacy,
    Bapatla, Guntur (district),
    Andhra Pradesh, Pin No: 522101,India

    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:11-12-2013

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    Y.Indira Muzib1,P. Jitendra kumar 2,V. Sai Kishore *3, M. Sandeep3, M.Suresh Babu4,P.Mallikharjuna rao5

    Title:Design and Development of chronopharmaceutical Drug Delivery of Lansoprazole
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Page No: (123-129)
  • Experimental Methods Keywords

    Methodology:Preparation of Cross-Linked Gelatin Capsules,Preparation of Lansoprazolegranules and tablets,Designing of Pulsincap etc
    Research Materials:Lansoprazole,


Lansoprazole wet granulation method hydrogel plug pulsing cap xanthan gum stability studies.

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