Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-PSPA-00001099
Title: Therapeutic Role of Nigella sativa on Turpentine Oil Induced Acute Inflammation in Rat Liver
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
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    The present study was performed to investigate the effect of herbal extract of N. sativa in Turpentine oil induced acute hyperlipidemia. Herbal extract of N. sativa was given orally at two doses levels (100 mg/Kg & 150 mg/Kg) for four weeks. Injection of non medicinal turpentine oil (0.2ml) before 6h of sacrificing was given to experimental group. Turpentine oil treated animals showed remarkable changes in inflammation and other lipid biochemical assays when compared to normal control. The 100mg/kg herbal extract treated rats showed significant increase of 25% in total antioxidant activity as compared to control induced hyperlipidemic. In conclusion the extract of N. sativa appeared to be safe and possibly protective against turpentine oil induced lipid peroxidation. However, further studies still to be needed prior to support its use in herbal medicine for hepatoprotection.

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    Author(s) Name:

    S ubodh K Chauhan1, RP Thapliyal1*, Sanjay K Ojha1, Himanshu Rai2, Puneet Singh2, Manendra Singh2, Amir Khan3

    Affiliation(s) Name:

    1Department of Biotechnology, H.N.B. Garhwal University, Srinagar, Garhwal, India
    2Department of Biotechnology, Uttaranchal College of Science & Technology, Dehradun, India
    3Department of Biochemistry, Faculty of Life Science, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Science & Research, Balawala, Dehradun, UK

    Corresponding Author:
    RP Thapliyal, Department of Biotechnology, H.N.B. Garhwal University, Srinagar, Garhwal, India
    Received; 15-06-2011; Accepted 23-07-2011

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    Author:

    S ubodh K Chauhan1, RP Thapliyal1*, Sanjay K Ojha1, Himanshu Rai2, Puneet Singh2, Manendra Singh2, Amir Khan3

    Title:Therapeutic Role of Nigella sativa on Turpentine Oil Induced Acute Inflammation in Rat Liver
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):2 (August)
    Year:2011
    Page No: (103-107)
  • Experimental Methods Keywords

    Methodology: Lipid peroxidation; Hyperlipidemia
    Research Materials:Nigella sativa

Keywords

Nigella sativa; Lipid peroxidation; Hyperlipidemia; Turpentine oil

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