Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000110
Title: Pharmacological investigation on the diuretic activity of the aqueous fruit extract of Neolamarckia cadamba (Roxb) bosser
Category: Pharmacology
Section: Research Article
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    The study was formulated to evaluate the efficacy of aqueous fruit extract of Neolamarckia cadamba on diuretic property in albino rats. Adult albino rats were randomly divided into five groups (n=8). All groups received normal saline (25 ml/kg). Group I which served as control received normal saline and animals which received standard diuretic drug furosemide (750mg/kg) were taken as diuretic control (group 2). Group 3 and group 4 received the fruit extract at a dose of 200 mg/kg and 400 mg/kg body weight. 24 h urine samples were collected by keeping the animals in metabolic cages. After 24 hrs of experiment, blood samples were collected from tail vein and serum was analyzed for creatinine concentration. Urine samples were analyzed for volume, pH, conductivity, urinary excretion, electrolyte concentration (Na+, K+, Cl-), Ca2+ , creatinine, creatinine clearance, glomerular filtration rate (GFR), saluretic, natriuretic and diuretic activity. The results were expressed in mean ± SE and analyzed with one way ANOVA. P< 0.05 was considered statistically significant. Significant dose dependant increase in serum creatinine, urine creatinine, creatinine clearance, glomerular filtration rate, saluretic and natriuretic activity was observed in the fruit extract treated groups. Urine volume, urinary excretion, electrolyte concentration and Ca2+ were also increased in the fruit extract treated groups when compared with controls. At a dose of 200mg/kg extract had moderate diuretic activity and a higher dose of 400mg/kg had good diuretic activity. The present study confirmed the effectiveness of aqueous fruit extract of N. cadamba as diuretic agent.

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    Author(s) Name:

    Prathibhakumari P. V and G. Prasad*

    Affiliation(s) Name:

    Department of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram, 695581-Kerala, India. 

    *Corresponding author.
    Dr. G. Prasad
    Department of Zoology,
    University of Kerala, Kariavattom, Thiruvananthapuram, 695581. Kerala,India

    E-mail:probios1@gmail.com


    Received on:08-01-2014; Revised on: 17-01-2014; Accepted on:20-01-2014

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    Author:

    Prathibhakumari P. V and G. Prasad*

    Title:Pharmacological investigation on the diuretic activity of the aqueous fruit extract of Neolamarckia cadamba (Roxb) bosser
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (130-135)
  • Experimental Methods Keywords

    Methodology:diuretic activity
    Research Materials:Neolamarckia cadamba (Roxb) bosser

Keywords

Neolamarckia cadamba diuretic activity furosemide glomerular filtration rate

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