Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-00001100
Title: Spectrophotometric Method for the Estimation of Eletriptan Hydrobromide in Pure and Tablet Dosage Forms
Category: Analytical Chemistry
Section: Research Article
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  • Abstract

    A simple efficient, precise and accurate spectroscopic method has been developed and validated for quantitative estimation of Eletriptan in bulk drug and pharmaceutical dosage form. Eletriptan is dissolved in Distilled Water and the resulting solution was then scanned in the UV range (200-400nm) in a 10 mm quartz cell in a double beam UV spectrophotometer. The λmax of Eletriptan was found to be 221nm.The method obeys Beers law in the concentration range from 2-10μg/ml. The correlation coefficient was found to be 0.99914 (r2 0.9991). The LOD and LOQ were found to be 0.6523 and 1.087mg/ml respectively. The result of estimation of marketed tablet formulation RELPAX (eletriptan)) was found to be 99.87% with their % RSD 0.7652%.The accuracy of the method was determined by recovery studies. The percentage recovery was found to be 99.56± 0.7632%. The method was validated statistically as per ICH guidelines. The method showed good reproducibility and recovery with % RSD less than 2. So, the proposed method was found to be simple, specific, precise, accuracy, linear, and rugged. The proposed method was successfully applied for the determination of Eletriptan in pharmaceutical formulations.

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    Author(s) Name:

    Kumara Swamy G*1, JMR Kumar2, JVLN Sheshagiri Rao3, U Ashok Kumar1, E Vinaya Snehalatha1

    Affiliation(s) Name:

    1Department of Pharmaceutical Analysis, Trinity College of Pharmaceutical sciences, Peddapalli, Karimnagar-505172, AP, India.
    2Holy Mary Institute of Technology and Science (HITS), Ghatkesar, Hyderabad
    3Department of pharmaceutical Analysis, Andhra University- 530003, AP

    Corresponding Author:
    Kumara Swamy G, Department of Pharmaceutical Analysis, Trinity College of Pharmaceutical sciences, Peddapalli, Karimnagar-
    505172.A.P. India.
    Received 30-04-2011; Revised 04-05-2011; Accepted 23-06-2011

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    Author:

    Kumara Swamy G*1, JMR Kumar2, JVLN Sheshagiri Rao3, U Ashok Kumar1, E Vinaya Snehalatha1

    Title:Spectrophotometric Method for the Estimation of Eletriptan Hydrobromide in Pure and Tablet Dosage Forms
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):2 (August)
    Year:2011
    Page No: (123-125)
  • Experimental Methods Keywords

    Methodology:Spectrophotometric Method
    Research Materials:Eletriptan

Keywords

Eletriptan; UV Spectroscopic method; Tablets.

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