Journal: Drug Invention Today

Article Id: JPRS-BSN-00001104
Title: Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice
Category: Biomaterials ( Synthetic and Natural )
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    Objective: The present study was carried out to investigate the effect of Dibenzo-α-pyrone derivatives on the course of pentylenetetrazole (PTZ)-induced chemical kindling and oxidative stress markers in PTZ-kindled mice. Methods: Kindling was induced by repeated injections of a subconvulsive dose of PTZ (25mg/Kg, i.p.) on alternate days for 5 weeks or until stage 5 of the seizure score was evoked on three consecutive administrations. Butylamine, Diethylamine and Pyrrolidine Derivatives of Dibenzo-α-pyrone were administered daily in three doses (10, 20 and 40mg/kg) per orally (p.o.) along with alternate day PTZ. Following PTZ kindling , oxidative stress parameters , i.e. levels of malondialdehyde (MDA) and reduced glutathione (GSH), were assessed in isolated homogenized whole brain tissue. Results: PTZ treatment progressively increased the seizure score in control mice. Biochemical analysis revealed a significant increase in MDA levels and decreased GSH levels in the brain homogenate of PTZ-kindled mice. Daily treatment with Butylamine, Diethylamine and Pyrrolidine Derivatives of Dibenzo-α -pyrone in doses of 20 and 40mg/kg significantly decreased the PTZ-induced seizure score. However, a low dose (10mg/kg) failed to improve the seizure score. Pretreatment of derivatives in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment. Conclusion: The present study indicate the potential anticonvulsant activity of Dibenzo-α-pyrone derivatives against PTZ-induced kindling in mice.

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    Author(s) Name:

    Shalini K. Sawhneya,* , Nidhi B. Agarwalb, Yatendra Kumara , Birendra Shrivastavac , Pankaj Sharmac

    Affiliation(s) Name:

    aITS paramedical (Pharmacy) College, Muradnagar, Ghaziabad, Uttar Pradesh, 201206 India
    bDepartment of Clinical Research, Faculty of Allied Health Sciences, Jamia Hamdard (Hamdard University), New Delhi-110062, India
    cSchool of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

    *Corresponding author.
    Shalini K. Sawhney
    ITS paramedical (Pharmacy) College,
    Muradnagar, Ghaziabad,
    Uttar Pradesh, 201206 India


    Received on: 05-05-2015; Revised on: 17-06- 2015; Accepted on:03-08-2015

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    Author:

    Shalini K. Sawhneya,* , Nidhi B. Agarwalb, Yatendra Kumara , Birendra Shrivastavac , Pankaj Sharmac

    Title:Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice
    Journal:Drug Invention Today
    Vol(issue):7(1)
    Year:2015
    Page No: (9-14)
  • Experimental Methods Keywords

    Methodology:Anticonvulsant And Antioxidant Actions, Pentylene –Induced Kindling Model
    Research Materials:Dibenzo-α-pyrone

Keywords

Epilepsy Dibenzo-α-pyrone pentylenetetrazole kindling oxidative stress

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