Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001110
Title: Evaluation of Combinational Therapy of Resveratrol and Black Tea Extract on Doxorubicin-induced Myocardial Infarction in Wistar Rats
Category: Pharmacology
Section: Research Article
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    Background: Cardiovascular and cancer problem is increasing day by day and causing untimely deaths worldwide. A continuous research is going on to develop new cardioprotective and anticancer drugs which are safe, economical and effective. Doxorubicin is a potent anticancer drug with restricted use due to cardio toxicity that it causes as side effect. Thus, any drug which will reduce its toxicity will be a boon for cancer patient. Herbal drugs are emerging as potent targets for research because they are cheap, locally available; having least reported side effects and generally being the part of our food culture. In view of this we have tried to evaluate the cardioprotective potential of resveratrol and black tea extract alone and in combination on the doxorubicin-induced myocardial infarction in rats. Methods: Thirty rats of Wistar albino strain were taken and divided into Control, Doxorubicin (DOX), Black Tea + DOX, Resveratrol + DOX, Black Tea + Resveratrol and Black Tea + Resveratrol + DOX treated groups. Various biochemical parameters were assessed to evaluate their antioxidant property and myocardial membrane integrity. Effect of these neutraceuticals on cellular architecture was also assessed by histopathological studies. Results and Discussions: Biochemical and histopathological investigations clearly showed the reversal of all the parameters towards normal indicating improvement in antioxidant status and reduction in cardiac damage. Conclusion: All the test drugs administered groups ; black tea-treated, resveratrol-treated and their combination-treated groups, showed cardio protection but the combination-treated group proved to be a better cardioprotective agent than the two drugs alone.

    Cite this article as: Ahmad Amanullah, Rustam Ekbbal and Syed Ehtaishamul Haque,Evaluation of Combinational Therapy of Resveratrol and Black Tea Extract on Doxorubicin-induced Myocardial Infarction in Wistar Rats,Journal of Pharmacy Research 2015,9(9),581-587

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    Author(s) Name:

    Ahmad Amanullah, Rustam Ekbbal and Syed Ehtaishamul Haque*

    Affiliation(s) Name:

    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India

    Received on:28-07-2015; Revised on: 17-08-2015; Accepted on: 22-09-2015

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    Author:

    Ahmad Amanullah, Rustam Ekbbal and Syed Ehtaishamul Haque*

    Title:Evaluation of Combinational Therapy of Resveratrol and Black Tea Extract on Doxorubicin-induced Myocardial Infarction in Wistar Rats
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (September)
    Year:2015
    Page No: (581-587)
  • Experimental Methods Keywords

    Methodology:myocardial infarction, antioxidant,biochemical parameters
    Research Materials:Resveratrol, black tea, doxorubicin

Keywords

Resveratrol black tea doxorubicin myocardial infarction antioxidant.

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