Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00001121
Title: Study on Acacia polyacantha for Controlling the Multi Drug Resistance in Enterobacteriaceae
Category: Microbiology
Section: Research Article
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    Background: The study carried out on the clinical samples possessing human bacterial pathogens possess drug resistance under in vitro conditions and further tested for the synergistic activity of Acacia polyacantha and antibiotics for better control. Aims and Objectives: Clinically isolated bacterial species were tested for their susceptibility against the thirty four antibiotics and determined for the antibiotic resistance using Kirby-Bauer method. Further several extracts of A. polyacantha were tested under synergistic study to select the best scored plant extract inhibiting maximum strains especially of E. coli and Proteus species in presence of antibiotics. Results and Discussion: Reduced zone of inhibition highlighted the present antibiotic resistance. In contrast, synergistic action of A. polyacantha methanolic extract of bark and leaf proved best in increasing the susceptibility in strains which showed prior resistance to antibiotics. Conclusion: Bacterial pathogens increasing in resistance and according to study combinational therapy may avert the cause of resistance if used carefully as evident with A. polyacantha extracts which improved the susceptibility even in those antibiotics which have showed complete resistance in E. coli and Proteus species.

    Cite this article as:Shweta M. Bhiwankar, Ashok V. Gomashe and Vijay N. Charde, Study on Acacia polyacantha for Controlling the Multi Drug Resistance in Enterobacteriaceae,Journal of Pharmacy Research 2015,9(11),606-611

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    Author(s) Name:

    Shweta M. Bhiwankar1*, Ashok V. Gomashe1 and Vijay N. Charde2

    Affiliation(s) Name:

    1Department of Microbiology, Shri Shivaji Science College, Congress Nagar, Nagpur (Maharashtra), India.440009
    2Department of Microbiology, Taywade College (Arts, Commerce and Science), Mahadula-Koradi, Dist. Nagpur (Maharashtra), India.440009

    Received on:09-07-2015; Revised on: 22-08-2015; Accepted on: 27-09-2015

    *Corresponding author.
    Shweta M. Bhiwankar
    Department of Microbiology,
    Shri Shivaji Science College,
    Congress Nagar, Nagpur
    (Maharashtra), India.440009

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    Author:

    Shweta M. Bhiwankar1*, Ashok V. Gomashe1 and Vijay N. Charde2

    Title:Study on Acacia polyacantha for Controlling the Multi Drug Resistance in Enterobacteriaceae
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (November)
    Year:2015
    Page No: (606-611)
  • Experimental Methods Keywords

    Methodology:Kirby-Bauer method
    Research Materials:Acacia polyacantha

Keywords

Acacia polyacantha; Clinical sample; Drug resistance; Enterobacteriaceae.

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