Journal: Journal of Pharmacy Research

Article Id: JPRS-BMB-00001122
Title: Antidiabetic and Antihyperlipidemic activity of Chrysoeriol in diabetic rats, role of HMG CoA reductase, LCAT and LPL: In vivo and in silico approaches
Category: Biochemistry and Molecular Biology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objective: Diabetes mellitus is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. The present study was designed to examine the antihyperlipidemic effect of Chrysoeriol (CS) in streptozotocin (STZ) induced diabetic rats. Methods: Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Results: Diabetic rats showed increased plasma glucose, Glycosylated Hb, total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density liprotein, atherogenic index and decreased insulin and high density lipoprotein in diabetic rats. The activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase significantly increased and decreased levels of lipoprotein lipase (LPL) and lecithin cholesterol acyltransferase (LCAT). In addition, the molecular docking of Chrysoeriol against HMG CoA reductase, LPL and LCAT involved in cholesterol biosynthesis using the Argus software. Diabetic rats were treated with Chrysoeriol shifted all these parameters towards normality. Chrysoeriol has shown the best ligand binding energy -7.59, -7.82 and -6.94 Kcal/mol. Conclusions: In conclusion, this study indicates that Chrysoeriol showed an antihyperlipidemic effect in addition to its antidiabetic effect in diabetic rats.

    Cite this article as:Krishnan Baskaran, Kodukkur Viswanathan Pugalendi and Ramalingam Saravanan,Antidiabetic and Antihyperlipidemic activity of Chrysoeriol in diabetic rats, role of HMG CoA reductase, LCAT and LPL: In vivo and in silico approaches,Journal of Pharmacy Research 2015,9(11),597-605.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Krishnan Baskaran, Kodukkur Viswanathan Pugalendi and

    Ramalingam Saravanan*

    Affiliation(s) Name:

    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Krishnan Baskaran, Kodukkur Viswanathan Pugalendi and

    Ramalingam Saravanan*

    Title:Antidiabetic and Antihyperlipidemic activity of Chrysoeriol in diabetic rats, role of HMG CoA reductase, LCAT and LPL: In vivo and in silico approaches
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (November)
    Year:2015
    Page No: (597-605)
  • Experimental Methods Keywords

    Methodology: Antidiabetic and Antihyperlipidemic activity
    Research Materials:Chrysoeriol

Keywords

Chrysoeriol Streptozotocin Antihyperlipidemic Diabetes mellitus 3-hydroxy 3-methylglutaryl coenzyme A reductase Lecithin cholesterol acyltransferase

Our Services

Most Downloaded List