Journal: Journal of Pharmacy Research

Article Id: JPRS-ND-0000114
Title: Potential Effect of Alpinia purpurata rhizome against Free radicals and Lipidperoxidation
Category: Natural Drugs
Section: Research Article
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    The aim of the study was to determine the free radical scavenging activities as well as the inhibition of in vitro lipid peroxidation evoked by Alpinia purpurata rhizome. The ethanolic extract of Alpinia purpurata was studied for its free radical scavenging property on different in vitro models like, Hydroxyl radical scavenging, Nitric Oxide Radical Scavenging, Super oxide radical scavenging activity and in vitro antilipidperoxidative assay using goat liver homogenate and RBC Ghost model. The results of ethanolic extract of Alpinia purpurata rhizome showed that a dose dependent increase in Hydroxyl radical scavenging, Nitric Oxide Radical Scavenging and Super oxide radical scavenging activity. In vitro anti-lipid peroxidative assay using goat liver homogenate and RBC Ghost model. The in vitro Lipid peroxidation (LPO) was inhibited to a good extent by the Alpinia purpurata rhizome ethanolic extract and the extent of inhibition being higher in the RBC membrane model than the liver homogenate model. The ethanolic extract showed good dose dependent free radical scavenging property in both the models. This study showed that inhibition of LPO and Hydroxyl radical, Nitric Oxide Radical and Super oxide radical scavenging abilities of Alpinia purpurata rhizome could be related to the presence of phenolic and flavonoid compounds. Therefore, the ethanolic extract of the rhizome may be a good source of natural antioxidative agent.

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    Author(s) Name:

    *1. Vadivel Subramanian and 2. Suja. S

    Affiliation(s) Name:

    *1.Department of Biochemistry,Dr.N.G.P Arts and Science College,Kalapatti road, Coimbatore-641 048,Tamilnadu, India
    2. Postgraduate and Research Department of Biochemistry, Dr. N.G.P. Arts and Science College, An Institution of Kovai Medical Center and Hospital (KMCH), Coimbatore- 641048, Tamilnadu, India

    *Corresponding author.
    Vadivel.Subramanian
    Department of Biochemistry,
    Dr.N.G.P Arts and Science College,
    Kalapatti road,Coimbatore-641 048,
    Tamilnadu,India

    Received on:21-11-2013; Revised on: 20-12-2013; Accepted on:22-01-2014

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    Author:

    *1. Vadivel Subramanian and 2. Suja. S

    Title:Potential Effect of Alpinia purpurata rhizome against Free radicals and Lipidperoxidation
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (148-151)
  • Experimental Methods Keywords

    Methodology:Lipid peroxidation, Freeradical scavenging
    Research Materials:Alpinia purpurata

Keywords

Lipid peroxidation Freeradical scavenging Alpinia purpurata.

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