Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001140
Title: Synthesis of Novel Trifluorobenzimidazole Derivatives and Their Study of 5-LOX Inhibition and Brine Shrimp Lethal Bioassay (BSLB)
Category: Pharmaceutical Chemistry
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    Here in we design and synthesized novel 2-(trifluoromethyl)-5-methyl-1-((5-aryl-1,3,4-oxadiazol-2-yl)methyl)-1H-benzimidazoles. All the synthesized compounds were well characterized by advanced analytical and spectrometrical methods (MS, 1H and 13C NMR) and evaluated for their 5-Lipoxygenase (5-LOX) inhibitory activity. Bio evaluation confirms that compound 7d exhibiting good inhibition with an IC50 value of 8.59 µg/mL against 5-LOX. In addition, the same compounds were further screened for in vitro cytotoxicity by Brine Shrimp Lethal Bioassay (BSLB). Compounds 7c and 7a showed potent cytotoxicity with an ED50 values 7.39 µg/mL and 7.54 µg/mL respectively.

    Cite this article as:Vara Prasad Yenugula, Praveen Choppara, Murthy Y.L.N*.Synthesis of Novel Trifluorobenzimidazole Derivatives and Their Study of 5-LOX Inhibition and Brine Shrimp Lethal Bioassay (BSLB), Journal of Pharmacy Research 2015,9(1),95-100.

     

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    Author(s) Name:

    Vara Prasad Yenugula, Praveen Choppara, Murthy Y.L.N*.

    Affiliation(s) Name:

    Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam, 530 003, India

    *Corresponding author.
    Murthy Y.L.N
    Department of Organic Chemistry, Foods,
    Drugs & Water, Andhra University,
    Visakhapatnam, 530 003, India


    Received on:22-10-2014; Revised on: 19-11-2014; Accepted on:25-01-2015

     

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    Author:

    Vara Prasad Yenugula, Praveen Choppara, Murthy Y.L.N*.

    Title:Synthesis of Novel Trifluorobenzimidazole Derivatives and Their Study of 5-LOX Inhibition and Brine Shrimp Lethal Bioassay (BSLB)
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (January )
    Year:2015
    Page No: (95-100)
  • Experimental Methods Keywords

    Methodology:Synthesis,Brine Shrimp Lethal Bioassay (BSLB)
    Research Materials: Novel Trifluorobenzimidazole Derivatives

Keywords

BSLB 5-LOX inhibition 1 3 4-oxadiazole Trifluorobenzimidazole.

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