Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001141
Title: Synthesis, characterization and biological evaluation of novel C-2 substituted benzimidazole heterocycles
Category: Pharmaceutical Chemistry
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    A series of new 1-(1H-benzo[d] imidazol-2-yl)-3-methyl-4-(substituted phenylhydrazono) -1H-pyrazol-5(4H)-ones (4a-i) were synthesized by the condensation of 2-hydrazinyl-1H-benzo[d]imidazole (2) with ethyl-2-arylhydrazono-3-oxobutyrates (3a-i) in glacial acetic acid. Also, 3-(1H-benzo[d]imidazol-2-ylamino)-2-(7-hydroxy-substituted-2-oxo-2H-chromen /quinolin -3-yl)thiazolidin-4-one)s (7a-d) were prepared via the cyclisation of Schiff bases 3-((2-(1H-benzo[d]imidazol-2-yl)hydrazono)substituted)-7-hydroxy-4-methyl-2H-chromen/quinolin-2-one (6a-d)with thioglycolic  acid in refluxing benzene. Structural assignments of these synthesized compounds were based on IR, 1HNMR, and Mass spectral data. The newly synthesized compounds (4a-i), (6a-d) and (7a-d) which possess a variety of heterocycles with benzimidazole as core nucleus were evaluated for their antimicrobial and anti-inflammatory activities by cup-plate method and formalin induced rat hind paw oedema method respectively.

    Cite this article as: Naganna M. Goudgaon and Sheshikant B. Ummapure,Synthesis, characterization and biological evaluation of novel C-2substituted benzimidazole heterocycles, Journal of Pharmacy Research 2015,9(12),643-649.

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    Author(s) Name:

    Naganna M. Goudgaon*a and Sheshikant B. Ummapureb

    Affiliation(s) Name:

    aDepartment of Post Graduate Studies and Research in Chemistry, Gulbarga University, Kalaburagi - 585 106, Karnataka, India.
    bDepartment of Chemistry, Central University of Karnataka, Kadaganchi, Kalaburagi – 585 367, Karanataka, India.

    *Corresponding author.
    Dr. N. M. Goudgaon
    Professor of Organic Chemistry
    Department of Chemistry,
    Gulbarga University, Kalaburagi - 585 106,
    Karnataka, India.

    Received on:20-09-2015; Revised on: 25-10-2015; Accepted on: 14-12-2015

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    Author:

    Naganna M. Goudgaon*a and Sheshikant B. Ummapureb

    Title:Synthesis, characterization and biological evaluation of novel C-2 substituted benzimidazole heterocycles
    Journal:Journal of Pharmacy Research
    Vol(issue):9(12)
    Year:2015
    Page No: (643-649)
  • Experimental Methods Keywords

    Methodology:Synthesis, characterization and biological evaluation
    Research Materials:novel C-2 substituted benzimidazole heterocycles

Keywords

Benzimidazole pyrazole coumarin quinoline thiazolidine antimicrobial and anti-inflammatory activity

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