Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001149
Title: Evaluation of antioxidant, antimicrobial and cytotoxic activities of Terminalia citrina Leaves
Category: Pharmacology
Section: Research Article
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  • Abstract

    Objective: To investigate antioxidant, antimicrobial and cytotoxic activities of methanol extract and its derived fractions (petroleum ether, carbon tetrachloride, dichloromethane and ethyl acetate) of leaves of Terminalia citrina plant belonging to the Combretaceae family. Methods: The antioxidant potential were evaluated in terms of total phenolic content, total flavonoid content, DPPH radical scavenging potential, ABTS scavenging potential, reducing power assay and total antioxidant capacity by specific standard procedures. The antimicrobial activity was evaluated using disc diffusion method while cytotoxic was evaluated by using brine shrimp lethality bioassay and compared with vincristine sulfate. Results: The methanolic leaf extract exhibited the highest flavonoid content and antioxidant capacity while ethyl acetate fraction exhibited the highest phenolic content, reducing power, DPPH and ABTS radical scavenging activity. Antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant. In case of antimicrobial and cytotoxic activities, the extracts of the leaves does not showed remarkable activities against tested microorganisms and Artemia salina respectively. Conclusions: This study suggests that the leaves of Terminalia citrina possess antioxidant activity.

    Cite this article as: Narhari Das, Durajan Goshwami, Md. Sharif Hasan, Zobaer Al Mahmud, Sheikh Zahir Raihan,Evaluation of antioxidant, antimicrobial and cytotoxic activities of Terminalia citrina Leaves,Journal of Pharmacy Research 2016,10(1),8-15.

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    Author(s) Name:

    Narhari Das*, Durajan Goshwami, Md. Sharif Hasan, Zobaer Al Mahmud, Sheikh Zahir Raihan

    Affiliation(s) Name:

    Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh 

    *Corresponding author.
    Narhari Das
    Department of Clinical Pharmacy & Pharmacology,
    Faculty of Pharmacy,
    University of Dhaka,
    Dhaka-1000, Bangladesh


    Received on:25-05-2015; Revised on: 17-11-2015; Accepted on: 28-12-2015

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    Author:

    Narhari Das*, Durajan Goshwami, Md. Sharif Hasan, Zobaer Al Mahmud, Sheikh Zahir Raihan

    Title:Evaluation of antioxidant, antimicrobial and cytotoxic activities of Terminalia citrina Leaves
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (January)
    Year:2016
    Page No: (8-15)
  • Experimental Methods Keywords

    Methodology: antioxidant, antimicrobial , cytotoxic activities
    Research Materials:Terminalia citrina Leaves

Keywords

Terminalia citrina Antioxidant Antimicrobial Cytotoxic activity

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