Journal: Journal of Pharmacy Research

Article Id: JPRS-BMB-00001151
Title: Effect of the methanol extract of the leaves of Azadirachta indica on ethanol-induced gastric ulcer in rats
Category: Biochemistry and Molecular Biology
Section: Research Article
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    Background and Aim:Plants have been the bases for medicinal treatments through much of human history and such medicine however, traditional, is still widely in use today such as the application of the leaves of Azadirachta indica in the treatment of gastric ulcer. The thrust of this work was therefore, to evaluate the effect of the methanol extract of the leaves of A. indica on ethanol-induced gastric ulcer in rats. Methods: The phytochemical constituents, acute toxicity and lethality and effects of the extract on ulcer index, gastric juice volume and gastric juice pH were assessed using standard methods. Results: The phytochemical screening revealed that the plant extract contained alkaloids, flavonoids, tannins, saponins, carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil but resins, reducing sugars and acidic compounds were not detected. The extract at a dose even as high as 5000 mg/kg body weight (b.w) was safe for administration. The extract at the tested doses [100, 200 and 400 mg/kg b.w] caused significant (p < 0.05) and dose-dependent decreases in ulcer indices (gastric lesions) and gastric juice volumes of the rats in the test groups compared to the values obtained for the rats in the positive control group (group 2). Significant (p < 0.05) and dose-related increases in gastric juice pH of the rats in the test groups compared to that of the rats in the positive control group were also brought about by the extract. The effects of the 400 mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion: These observations show that the methanol extract of the leaves of A. indica possesses notable anti-ulcer effect and contains some pharmacologically active principles which might be cynosures of future modern anti-ulcer drugs.

    Cite this article as:Christian E. Odo,Effect of the methanol extract of the leaves of Azadirachta indica on ethanol-induced gastric ulcer in rats, Journal of Pharmacy Research 2016,10(1),41-45.

     

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    Author(s) Name:

    Christian E. Odo

    Affiliation(s) Name:

    Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria

    *Corresponding author.
    Christian E. Odo
    Department of Biochemistry,
    College of Natural Sciences,
    Michael Okpara University of Agriculture,
    Umudike, PMB 7267 Umuahia,
    Abia State, Nigeria

    Received on:21-09-2015; Revised on: 26-10-2015; Accepted on: 29-12-2015

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    Author:

    Christian E. Odo

    Title:Effect of the methanol extract of the leaves of Azadirachta indica on ethanol-induced gastric ulcer in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (January)
    Year:2016
    Page No: (41-45)
  • Experimental Methods Keywords

    Methodology:ethanol-induced gastric ulcer,phytochemical constituents, acute toxicity, lethality ,ulcer index, gastric juice volume and gastric juice pH
    Research Materials:Azadirachta indica

Keywords

Traditional medicine Azadirachta indica Gastric ulcer and Cimetidine

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