Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-PC-00001159
Title: Evaluation of the Angiosuppresive Activity of Prodigiosin Using the Chorioallantoic Membrane Assay
Category: Pharmaceutical Chemistry
Section: Research Article
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    Angiogenesis is a process of new blood vessel development that performances a crucial function in embryonic development and many pathological situation encompassing cancer. The potential use of natural products in antiangiogenesis is to be appreciated especially their role in chemoprevention. In the present study, we investigated the antiangiogenic properties of red pigment isolated from marine bacteria Vibrio sps. This pigment was further purified and characterized by physical and chemical characteristics using TLC, UV–vis Spectroscopy, NMR H, and C NMR and confirmed as prodigiosin. The chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of prodigiosin. The antiangiogenic activity of prodigiosin implicates their possible application for diseases where inhibition of blood vessel formation is desired.

    Cite this article as: Pabba Shiva Krishna, Gudikandula Krishna, Laxminarayana Eppakayala, Reddy Shetty Prakasham and M.A.Singara Charya ,Evaluation of the Angiosuppresive Activity of Prodigiosin Using the Chorioallantoic Membrane Assay,International Journal of Chemical and Analytical Science 2014,5(1),33-38

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    Author(s) Name:

    Pabba Shiva Krishna,1 Gudikandula Krishna,1 Laxminarayana Eppakayala2, Reddy Shetty Prakasham3 and M.A.Singara Charya1

    Affiliation(s) Name:

    1Department of Microbiology, Kakatiya University, Warangal,-506009 A.P, India
    2Department of Physics and Chemistry, Mahatma Gandhi Institute of Technology, Gandipet, Hyderabad-500075 (A.P.) India
    3Bioengineering and Environmental Centre, Indian Institute of Chemical Technology, Hyderabad, 500607, India.

    *Corresponding author.
    M.A.Singara Charya
    Department of Microbiology,
    Kakatiya University,
    Warangal,-506009 A.P, India


    Received on: 17-11-2013; Revised on: 29-12-2013; Accepted on:07-01-2014

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    Author:

    Pabba Shiva Krishna,1 Gudikandula Krishna,1 Laxminarayana Eppakayala2, Reddy Shetty Prakasham3 and M.A.Singara Charya1

    Title:Evaluation of the Angiosuppresive Activity of Prodigiosin Using the Chorioallantoic Membrane Assay
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):5 (January)
    Year:2014
    Page No: (33-38)
  • Experimental Methods Keywords

    Methodology:Angiosuppresive Activity,chorioallantoic-membrane
    Research Materials:prodigiosin

Keywords

Angiogenesis red pigment prodigiosin chorioallantoic-membrane

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