Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000116
Title: Development of Novel Indole Molecules for the Screening of Anti-inflammatory Activity
Category: Pharmaceutical Chemistry
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones were prepared from 5-hydroxy isatin. A mixture of 5-hydroxy isatin, dialkylamino alkylhalide in alcoholic potassium hydroxide was stirred at room temperature for 6 hours to get the 5-[2(3)-dialkylamino alkoxy] Indole 2,3-diones. The structures of the products were characterized by IR, NMR, MASS Spectral studies. All the compounds were evaluated for anti-inflammatory activity. Some of these compounds showed good anti-inflammatory activity compared with standard compounds.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    K.Swathi* and M. Sarangapani

    Affiliation(s) Name:

    Medicinal Chemistry Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Wararagal-506009, A.P., India

    *Corresponding author.
    K.Swathi
    Medicinal Chemistry Laboratory,
    University College of Pharmaceutical Sciences,
    Kakatiya University,
    Wararagal-506009, A.P., India
    Email: kswathi84@yahoo.co.in

    Received on:18-11-2013; Revised on: 20-12-2013; Accepted on:24-01-2014

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    K.Swathi* and M. Sarangapani

    Title:Development of Novel Indole Molecules for the Screening of Anti-inflammatory Activity
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (162-166)
  • Experimental Methods Keywords

    Methodology:Carrageenan - induced rat paw edema method
    Research Materials:5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones,

Keywords

Synthesis 5-[2(3)-dialkylamino alkoxy] Indole 2 3-diones Antiinflamatory activity.

Our Services

Most Downloaded List