Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000117
Title: Formulation by 23 factorial design and evaluation of controlled release transdermal patches of metoprolol succinate
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The aim of present investigation is the development and evaluation of Transdermal drug delivery system for Selective β1 receptor blocker of Metoprolol succinate. Optimization of formulations of matrix transdermal patches was carried out by 23 factorial design. Formulation of controlled release matrix transdermal patches of Metoprolol succinate was done by solvent casting method by using different polymers like HPMC K4M, PVP K30 and Eudragit RL100. Formulated matrix transdermal patches were evaluated for physiochemical parameters like thickness and weight, Flatness, Folding endurance, Mechanical strength, Percentage moisture absorption, Percentage moisture loss, Water vapor transmission rate and Drug content. Surface morphology was examined by Scanning electron microscopy. All prepared formulations indicated good physical stability. Skin irritation studies were performed through rat skin by Draize scoring method. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. The satisfactory results were obtained in all prepared formulation and based on the results MP14 (HPMCK4M-71.25mg, PVP K30-4.75mg and Eudragit RL100-19mg) was the best one when compared to other. The in-vitro kinetics shows the zero order drug release followed by non-fickian diffusion mechanism.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    G. Saravanan*1, Sarath Chandiran Irisappan 2, K.N. Jayaveera 3

    Affiliation(s) Name:

    1*Assistant Professor, Dr. Samuel George Institute of Pharmaceutical Sciences, Markapur-523316, Andhra Pradesh, India
    2 Professor & Principal, Gokula Krishna College of Pharmacy, Sullurpet-524121, Nellore dist, Andhra Pradesh, India
    3 Prof & Head, Department of Chemistry, JNTU Anantapur, Anantapuram – 515 002, Andhra Pradesh, India.

    *Corresponding author.
    G. Saravanan
    Assistant Professor,
    Dr. Samuel George Institute of Pharmaceutical Sciences,
    Markapur-523316,
    Andhra Pradesh, India.
    Email: saravanan.nila@gmail.com

    Received on:21-11-2013; Revised on: 12-12-2013; Accepted on:10-01-2014

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    G. Saravanan*1, Sarath Chandiran Irisappan 2, K.N. Jayaveera 3

    Title:Formulation by 23 factorial design and evaluation of controlled release transdermal patches of metoprolol succinate
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Year:2014
    Page No: (167-173)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Metoprolol succinate

Keywords

Metoprolol succinate Factorial design solvent casting method Draize scoring method In-vitro permeation studies Franz diffusion cell.

Our Services

Most Downloaded List