Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001175
Title: Effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats
Category: Pharmacology
Section: Research Article
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    Background and Aim:Gastric ulceration may involve bleeding which in extreme cases could result in haematologic abnormalities such as anaemia among others. This research was therefore, designed to ascertain the effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats. Methods:The effects of the methanol extract of the leaves of A. indica on red blood cell (RBC) count, packed cell volume (PCV), concentration of haemoglobin (Hb) and total white blood cell (tWBC) count were determined with the aids of standard methods. Results:The extract at the graded doses [100, 200 and 400 mg/kg body weight (b.w)] significantly (p < 0.05) and dose-dependently increased the RBC counts, PCV values, Hb concentrations and tWBC counts of the rats in the test groups compared to the values obtained for the rats in the positive control group (group 2). The effects of the 400 mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion:The methanol extract of the leaves of A. indica remarkably improved the haematological parameters in the ulcerated rats and hence may raise the choice of the plant over some other plants for the treatment of gastric ulcer especially when the ulcer is bleeding-prone.

    Cite this article as:Christian E. Odo,Effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats,Journal of Pharmacy Research 2016,10(1),54-57.

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    Author(s) Name:

    Christian E. Odo

    Affiliation(s) Name:

    Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria

    *Corresponding author.
    Christian E. Odo
    Department of Biochemistry,
    College of Natural Sciences,
    Michael Okpara University of Agriculture,
    Umudike, PMB 7267 Umuahia, Abia State, Nigeria

    Received on:26-11-2015; Revised on: 28-12-2015; Accepted on: 12-01-2016

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    Author:

    Christian E. Odo

    Title:Effects of the methanol extract of the leaves of Azadirachta indica on some haematological parameters of ethanol-ulcerated rats
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (January)
    Year:2016
    Page No: (54-57)
  • Experimental Methods Keywords

    Methodology:Gastric ulceration, anaemia,haematological parameters
    Research Materials:Azadirachta indica

Keywords

Gastric ulceration anaemia Azadirachta indica and haematological parameters

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