Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001176
Title: Effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats
Category: Pharmacology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background and Aim: Increased needs for proteins and anti-oxidants are required to promote wound healing and thus, this study was originated to evaluate the effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats. Methods : The effects of the methanol extract of the leaves of A. indica on the concentration of total proteins and specific activity of catalase were determined and assayed respectively using standard methods. Results: The extract at the three doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p < 0.05) and dose-related increases in the concentration of total proteins and specific activity of catalase in the rats of the test groups compared to those of the rats in the ulcer-untreated group (group 2). The 400 mg/kg b.w of the extract exerted the greatest effects in a manner similar to those of the standard anti-ulcer drug, cimetidine at the dose of 100 mg/kg b.w. Conclusion: The remarkable amelioration of the amount of total proteins and specific activity of catalase in the ulcerated rats by the methanol extract of the leaves of A. indica encourages the local utilisation of the leaves of the plant in the treatment of gastric ulcer.

    Cite this article as:Christian E. Odo,Effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats,Journal of Pharmacy Research 2016,10(1),65-68.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Christian E. Odo

    Affiliation(s) Name:

    Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria

    *Corresponding author.
    Christian E. Odo
    Department of Biochemistry,
    College of Natural Sciences,
    Michael Okpara University of Agriculture,
    Umudike, PMB 7267 Umuahia, Abia State, Nigeria

    Received on:16-11-2015; Revised on: 21-12-2015; Accepted on: 13-01-2016

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Christian E. Odo

    Title:Effects of the methanol extract of the leaves of Azadirachta indica on the concentration of total proteins and specific activity of catalase in ethanol-ulcerated rats
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (January)
    Year:2016
    Page No: (65-68)
  • Experimental Methods Keywords

    Methodology:total proteins,catalase activity
    Research Materials:Azadirachta indica

Keywords

Proteins Azadirachta indica Catalase and Gastric ulcer

Our Services

Most Downloaded List