Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001203
Title: Direct compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The aim of this study was to develop and optimize cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets without changes in the release profile. In order to avoid segregation problems resulting from particle size differences between coated pellets and excipients and to protect the integrity of brittle ethyl cellulose coating during compression the tabletting excipients were layered on to the ethyl cellulose (6%) coated metoprolol succinate pellets. However, the drug release from these cushion layered pellets increased upon compression. Incorporation of a glidant (magnesium stearate) between the cushion layer and ethyl cellulose coating reduced the compression effect on the drug release. Glidant was coated to a coating level of 1-3%. The F2 values of optimized formulation (directly compressed cushion layered formulation with 3% magnesium stearate) was found to be greater than 50 and showed similar release as that of uncompressed pellets. The directly compressed cushion layered pellets protected the pellet coating significantly better from damages during compression when compared to the conventional compression of coated pellets and also facilitated segregation free compression of an extended release ethyl cellulose coated pellets in to fast disintegrating tablets.

    Cite this article as:M.Yasmin Begum, G.Pavani,M.Sudhakar,Direct compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets,Journal of Pharmacy Research 2016,10(1),69-75.

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    Author(s) Name:

    M.Yasmin Begum1*, G.Pavani1 , M.Sudhakar

    Affiliation(s) Name:

    1*Department of Pharmaceutics, Malla Reddy College of Pharmacy (affiliated to Osmania University), Hyderabad, Andhra Pradesh, India

    *Corresponding author.
    Dr.M.Yasmin Begum, M.Pharm., Ph D,
    Professor,
    Department of Pharmaceutics,
    Malla Reddy College of Pharmacy
    (affiliated to Osmania University),
    House No 12-2-826/A/41, L.I.C.Colony,
    Mehdipatanam,Hyderabad – 500028,India.


    Received on:22-10-2015; Revised on: 14-11-2015; Accepted on: 08-01-2016

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    Author:

    M.Yasmin Begum1*, G.Pavani1 , M.Sudhakar

    Title:Direct compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (January)
    Year:2016
    Page No: (69-75)
  • Experimental Methods Keywords

    Methodology:extended release, multiparticulate pellets,Direct compression
    Research Materials:metoprololol succinate

Keywords

ethyl cellulose coating magnesium stearate extended release multiparticulate pellets metoprololol succinate.

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