Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-0000121
Title: Increasing Prevalence of Extended Spectrum Beta Lactamase Producing Microorganisms: A review
Category: Microbiology
Section: Review Article
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    The development of antibiotic resistance in various species of bacteria following introduction of antimicrobial agents has emerged as an important medical problem everywhere in the world including India. Extended spectrum beta lactamases (ESBLs) are rapidly evolving group of beta lactamase enzymes produced by the Gram negative bacteria. Beta-lactam antibiotics are the largest and most commonly used group of antimicrobial agents world-wide. They show very good tolerability and many of the drugs can be administrated orally. Bacteria expressing extended-spectrum beta-lactamases (ESBLs), enzymes hydrolyzing penicillins and cephalosporins, may not respond to therapy using some of these antibiotics. These enzymes are found most commonly in the Enterobacteriaceae family, and organisms that produce ESBLs are often resistant to non-beta lactam antibiotics, such as fluoroquinolones and aminoglycosides, by additional mechanisms, thus further limiting treatment options. At present, ESBLs has been increasing as a serious nosocomial and community pathogen having the property multidrug resistance. It is a great challenge for clinician to treat these bacterial infections. There was a limited number of drugs sensitive for these bacteria, the only drug of choice is imipenem, followed by amikacin in injectable form. But most probably in near future, if this irrational use is not stopped, infection with that Gram negative bacteria increase the rate of resistant to drugs that are now sensitive, resulting increase morbidity and mortality. Infection-control practitioners and clinicians need the clinical laboratory to rapidly identify and characterize different types of resistant bacteria specially ESBLs efficiently to minimize the spread of these bacteria and help to select more appropriate antibiotics.

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  • About the authors and Affiliations

    Author(s) Name:

    Sajitha M K*, Dilip. C, Danisha P, Molniya Baby , LinuMohan.P, Shinu.C

    Affiliation(s) Name:

    Department of Pharmacy practice, Al Shifa College of Pharmacy, Poonthanam, Khizhattur, Perinthalmanna, Kerala, India.


    *Corresponding author.
    Dilip. C
    Associate professor
    Alshifa College of Pharmacy
    Poonthanam P.O
    Perinthalmanna, Kerala-679325,India.

    Received on:21-11-2013; Revised on: 08-12-2013; Accepted on:11-12-2013

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    Sajitha M K*, Dilip. C, Danisha P, Molniya Baby , LinuMohan.P, Shinu.C

    Title:Increasing Prevalence of Extended Spectrum Beta Lactamase Producing Microorganisms: A review
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (February)
    Page No: (183-186)
  • Experimental Methods Keywords

    Research Materials: Antimicrobial agents


Antimicrobial agents Prevalence Resistance pattern

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