Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001212
Title: Incorporation of METHOCEL E6 PLV by a Novel Foam Granulation Technique for Dissolution Augmentation of the Poor Soluble Silymarin
Category: Pharmaceutics
Section: Research Article
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    Objective: In the present study Foam Granulation Technique (FGT) TM was employed in the development of IR tablets of high dose of silymarin dried plant extract which is a very fine, poorly compressible material with poor water solubility and these characteristic features poses extensive technological challenge in its manufacturing. Methods: In FGT, the Methocel E6 PLV was used as foam binder in varying concentrations of 1%, 5%, 7% and 10%. The evaluation of potentially important foam properties, foam penetration mechanism assessment and tablet evaluation was carried out in details and compared with direct compression tablet of silymarin. Results and Discussion: The foam penetration followed foam drainage controlled mechanism and was found to be less dependent on the powder hydrophobicity compared to water drop which followed drop controlled mechanism. The foam induced nucleation successfully created nuclei with relatively uniform structure, size and sphericity as compared to water. The dissolution profile of silymarin foam bonded tablets with 5% Methocel E6 exhibited better dissolution profiles with T20%, T50%, T75% at 6, 30 and 120 min, when compared with direct compression control tablets with T20% at 120 min. The drug release from optimized 5% foam tablets followed Higuchi model with R2 = 0.8831 and were found to be stable in accelerated stability studies for a period of 3 months. Conclusion: Thus silymarin with high dose-low solubility characteristics can be easily formulated into IR tablet for clinical and commercial use using this helpful technique.

    Cite this article as: Shamama Javed, Kanchan Kohli, Waquar Ahsan,Incorporation of METHOCEL E6 PLV by a Novel Foam Granulation Technique for Dissolution Augmentation of the Poor Soluble Silymarin,Journal of Pharmacy Research 2016,10(2),79-89.

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    Author(s) Name:

    Shamama Javed1, Kanchan Kohli1*, Waquar Ahsan2

    Affiliation(s) Name:

    1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard University, New Delhi 110062, India.
    2Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arab.

    *Corresponding author.
    Dr. Kanchan Kohli, Associate Professor,
    Department of Pharmaceutics,
    Faculty of Pharmacy,
    Jamia Hamdard University,
    New Delhi 110062, India. 

    Received on:27-11-2015; Revised on: 16-12-2015; Accepted on: 28-01-2016

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    Author:

    Shamama Javed1, Kanchan Kohli1*, Waquar Ahsan2

    Title:Incorporation of METHOCEL E6 PLV by a Novel Foam Granulation Technique for Dissolution Augmentation of the Poor Soluble Silymarin
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (February)
    Year:2016
    Page No: (79-89)
  • Experimental Methods Keywords

    Methodology:Dissolution,,Foam binder, Granulation, Solubility.
    Research Materials:Silymarin

Keywords

Silymarin Dissolution Methocel E6 PLV Foam binder Granulation Solubility.

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