Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-00001213
Title: Formulation and Evalution of Immediate Release Tablets of Fexofenadine Hydrochloride
Category: Quality Assurance
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablets were prepared and evaluated pre and post compressional parameters. In-Vitro Disintegration study shows that as there is increase in disintegration time with increase in concentration of sodium starch glycolate while there is decrease in disintegration time with increase in the level of crospovidone. The results indicate that the selected batch of tablet formulation containing crospovidone provides disintegration time between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis.

    Cite this article as:Sachin Gholve, Ganesh Todkar, Sharad Barhate, Ranjana Suryawanshi, Omprakash Bhusnure,Formulation and Evalution of Immediate Release Tablets of Fexofenadine Hydrochloride,Journal of Pharmacy Research 2016,10(2),90-96.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Sachin Gholve1*, Ganesh Todkar2, Sharad Barhate1, Ranjana Suryawanshi1, Omprakash Bhusnure1

    Affiliation(s) Name:

    1 Department of Quality Assurance, Channabasweshwar Pharmacy College (Degree),
    2 Department of Pharmaceutics, Channabasweshwar Pharmacy College (Degree),
    Kava Road, Basweshwar Chowk, Latur, Maharashtra, India-413512

    *Corresponding author.
    Mr. Sachin Gholve, M.Pharm, Ph.D Scholar
    Department of Quality Assurance,
    Channabasweshwar Pharmacy College (Degree),
    Kava Road, Basweshwar Chowk, Latur,
    Maharashtra, India-413512


    Received on:28-11-2015; Revised on: 15-12-2015; Accepted on: 12-01-2016

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Sachin Gholve1*, Ganesh Todkar2, Sharad Barhate1, Ranjana Suryawanshi1, Omprakash Bhusnure1

    Title:Formulation and Evalution of Immediate Release Tablets of Fexofenadine Hydrochloride
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (February)
    Year:2016
    Page No: (90-96)
  • Experimental Methods Keywords

    Methodology:Formulation and Evaluation,Direct compression method,pre and post compressional parameters,In-Vitro Disintegration study
    Research Materials:Fexofenadine Hydrochloride

Keywords

Allergic rhinitis Crospovidone Croscarmellose sodium.

Our Services

Most Downloaded List