Journal: Journal of Pharmacy Research

Article Id: JPRS-PB-00001214
Title: In vitro studies on the wound dressing prepared using collagen and teak leaves (Tectonagrandis)
Category: Pharmaceutical Biotechnology
Section: Research Article
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    The inappropriate caring of the burn wound may delay its healing, causing the area to become infected and subsequently resulting in chronic wounds. In this study, methanolic teak leaves extract (Tectonagrandis) has been incorporated into collagen sheet and the bio-composite has been evaluated for its physical, biological properties and also its in-vitro wound healing efficacy using 3T3 fibroblast cell line. This composite sheet is cost-effective, as collagen is being extracted from chrome shavings a by product of tanneries, in which teak extract is incorporated. The results showed that addition of teak leaves extract increased the water absorption capacity (184 %), tensile strength properties (1.11 N/mm2) and also stability of composite sheet against lysozyme. The characteristic spectra of collagen is shown by IR spectrum of amide I, II and III absorption bands at 1663, 1555 and 1242 cm-1 respectively. The bio-composite sheets have exhibited anti-microbial properties and extract release studies show 80 % extract release in 4 hrs. MTT based proliferation assay shows that collagen–teak bio composite sheets are not cytotoxic to cells and also supports the growth and proliferation as indicated by increase in cell number with respect to time.

    Cite this article as: Trikkurmadom Seetharaman Amritha, VijiChandran S, Rajalekshmy G, Sujatha S,Pandima Devi M,In vitro studies on the wound dressing prepared using collagen and teak leaves (Tectonagrandis),Journal of Pharmacy Research 2016,10(2),97-105.

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    Author(s) Name:

    Trikkurmadom Seetharaman Amritha, VijiChandran S, Rajalekshmy G, Sujatha S,Pandima Devi M*

    Affiliation(s) Name:

    Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu 603203,India.

    *Corresponding author.
    Pandima Devi M
    Department of Biotechnology,
    School of Bioengineering, SRM University,
    Kattankulathur,Tamil Nadu 603203,India.


    Received on:22-11-2015; Revised on: 17-01-2016; Accepted on: 20-02-2016

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    Author:

    Trikkurmadom Seetharaman Amritha, VijiChandran S, Rajalekshmy G, Sujatha S,Pandima Devi M*

    Title:In vitro studies on the wound dressing prepared using collagen and teak leaves (Tectonagrandis)
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (February)
    Year:2016
    Page No: (97-105)
  • Experimental Methods Keywords

    Methodology:Isolation and preparation of Collagen,Physical Characterization,Biological characterization
    Research Materials:teak leaves,collagen

Keywords

Wound dressing collagen teak leaves biocomposites in vitro 3T3 fibroblast

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