Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001221
Title: Swelling Approach A Novel Method For Gastric Retention
Category: Pharmaceutics
Section: Research Article
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    Present investigation deals with the preparation and characterization of swellable gastroretentive drug delivery system of Pregabalin containing Psyllium Husk, HPMC K4M, Crosspovidone and Polyvinylpyrolidone, as the polymers. The swellable gastroretentive drug delivery system tablets were prepared by wet granulation method. Nine formulations were developed which differed in the ratio of polymers. Formulations PRF-1, PRF-2, PRF-3, PRF-4, PRF-5, PRF-6, PRF-7, PRF-8 and PRF-9 were composed of Psyllium Husk, HPMC K4M, Crosspovidone and Polyvinylpyrolidone respectively. All the formulations were evaluated for swelling index, Mucoadhesive Strength, Mucoadhesive force, Mucoadhesive time and in vitro drug release study. In vitro drug release study was performed using United State Pharmacopoeia (USP) type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 ml of 0.1N HCl maintained at 37ºC ± 0.5ºC as the dissolution medium. On the basis of evaluation parameter formulation PRF-5 was selected as developed formulation. Therefore, it can be concluded that the swellable gastroretentive drug delivery system may be exploited successfully for the delivery of drugs such as Pregabalin.

    Cite this article as:Lahoti Swaroop Rameshwarji, Shep Santosh Gyandev,Swelling Approach A Novel Method For Gastric Retention, Journal of Pharmacy Research 2016,10(2),120-125.

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    Author(s) Name:

    Lahoti Swaroop Rameshwarji1, Shep Santosh Gyandev2*

    Affiliation(s) Name:

    1Department of Pharmaceutics, Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India
    2Department of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer (Rajasthan), India 305001.

    *Corresponding author.
    Mr. Santosh Gyandev Shep
    Research scholar,
     Department of Pharmaceutical Sciences,
    Bhagwant University, Sikar Road,
    Ajmer (Rajasthan), India 305001.

    Received on:25-12-2015; Revised  on:  10-11-2016; Accepted on: 20-02-2016   

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    Author:

    Lahoti Swaroop Rameshwarji1, Shep Santosh Gyandev2*

    Title:Swelling Approach A Novel Method For Gastric Retention
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (February)
    Year:2016
    Page No: (120-125)
  • Experimental Methods Keywords

    Methodology:Swelling Approach,Gastroretentive, Mucoadhesive.
    Research Materials: Swellable drugs

Keywords

Swellable Gastroretentive Mucoadhesive.

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