Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001222
Title: Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
Category: Pharmaceutical Chemistry
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    The free radical scavenging activity of triazole analogues was estimated by the novel spectrophotometric method. The antioxidant property of triazole is influenced to a great extent by the increase in the strength of electron donating group attached on five member triazole ring. The semi empirical quantum chemical methods, AM1 and PM3 were used to estimate different physicochemical parameters. The electron affinity and softness were found to be responsible for high antioxidant activity. Docking studies were also performed with the active site of cyclo-oxygenase-2 to identify hydrogen bonding, hydrophobic and ionic interactions. The suitable chemical environment of triazole analogues for high efficacy is proposed.

    Cite this article as: Ramesh Macha, K. Ravindrachary, M. Himabindu,  Perka Shyam,  R.Rajesh, G.P.L.Jayasree , Parthasarathy Tigulla,Triazole analogues as novelantioxidants: In vitro bioassay and molecular modeling studies,Journal of Pharmacy Research 2016, 10(3),136-145.

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    Author(s) Name:

    Ramesh Macha1*, K. Ravindrachary2, M. Himabindu4,  Perka Shyam1,  R.Rajesh1, G.P.L.Jayasree3 , Parthasarathy Tigulla1

    Affiliation(s) Name:

    1Department of chemistry, Osmania University Hyderabad- 500007, Telangana State, India
    2Dept. of chemistry, Sri Venkateshwara College, Suryapet, Nalgonda, Telangana State, India
    3Department of Biotechnology, Sreenidhi Institute of Science and Technology (SNIST),Hyderabad, Telangana State, India
    4Department of  chemistry, Muffakham jah College of Engineering and Technology, Telangana State, India

    *Corresponding author.
    Dr. Ramesh Macha
    Department of chemistry,
    Osmania University
    Hyderabad- 500007,
    Telangana State, India

    Received on:16-11-2015; Revised  on:  14-02-2016; Accepted on: 08-03-2016   

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    Author:

    Ramesh Macha1*, K. Ravindrachary2, M. Himabindu4,  Perka Shyam1,  R.Rajesh1, G.P.L.Jayasree3 , Parthasarathy Tigulla1

    Title:Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
    Journal:Journal of Pharmacy Research
    Vol(issue):10(3)
    Year:2016
    Page No: (136-145)
  • Experimental Methods Keywords

    Methodology:Spectrophotometer, Antioxidant, QSAR, Cyclo-oxygenase-2 inhibitor
    Research Materials:Triazole analogues

Keywords

Triazoles Spectrophotometer Antioxidant QSAR Cyclo-oxygenase-2 inhibitor

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