Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001242
Title: Formulation development and evaluation of Carbamazepine fast dissolving tablets
Category: Pharmaceutics
Section: Research Article
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    Background: The main objective of present research work is to formulate the Carbamazepine Fast Dissoving tablets. Carbamazepine, an antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by blocking use-dependent sodium channels. Methods: The Fast Dissoving tablets of Carbamazepine were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Sperdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables. Results and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 9.375% Crospovidone and 9.375% Croscarmellose, is the most similar formulation (similarity factor f2=82.675, dissimilarity factor f1= 2.049 & No significant difference, t= 0.041) to marketed product (TEGRETOL-100). Conclusion: The selected formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.665).

    Cite this article as: Raghavendra Kumar Gunda, J. N. Suresh Kumar, V. Satyanarayana, Swathi Batta, Ch . Meher Harika,Formulation development and evaluation of Carbamazepine  fast dissolving tablets,Journal of Pharmacy Research 2016,10(5),216-225.

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    Author(s) Name:

    Raghavendra Kumar Gunda*1, J. N. Suresh Kumar1, V. Satyanarayana2, Swathi Batta3, Ch . Meher Harika1

    Affiliation(s) Name:

    1Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences,
    Narasaraopet, Guntur (Dt), Andhra Pradesh-522601, India.
    2Department of Pharmacy Practice, Narasaraopeta Institute of Pharmaceutical Sciences,
    Narasaraopet, Guntur (Dt), Andhra Pradesh-522601, India.
    3Department of Pharmaceutics, Priyadarshni Institute of Pharmaceutical Education and Research, Guntur , Andhra Pradesh-522017, India.

    *Corresponding author.
    Mr. Raghavendra Kumar Gunda M.Pharm
    Assistant Professor,
    Department of Pharmaceutics,
    Narasaraopeta Institute of Pharmaceutical Sciences,
    Narasaraopet, Guntur(D.t), A.P. India-522601.


    Received on:14-02-2016; Revised on: 20-03-2016; Accepted on: 29-04-2016

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    Author:

    Raghavendra Kumar Gunda*1, J. N. Suresh Kumar1, V. Satyanarayana2, Swathi Batta3, Ch . Meher Harika1

    Title:Formulation development and evaluation of Carbamazepine fast dissolving tablets
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (May)
    Year:2016
    Page No: (216-225)
  • Experimental Methods Keywords

    Methodology:Formulation development and evaluation,32 Factorial Design,Wetting Time, Disintegration Time.
    Research Materials:Carbamazepine

Keywords

Carbamazepine 32 Factorial Design Crospovidone croscarmellose Sodium Wetting Time Disintegration Time.

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