Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001285
Title: Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background: Sugaheal®, the 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) isolated from the seed of Trigonella foenum graecum (Linn.) is a well established antidiabetic drug. Several experiments have revealed that Sugaheal® also possesses good antioxidant characteristics. Gastric ulcer generally develops due to long term use of Non-Steroidal Anti Inflammatory Drugs (NSAIDs), consumed as pain killers. It is well established that oxidative stress and free radical mediated injury play a major role in generation of gastric ulcer. This influenced us to investigate the ameliorative role, if any, of Sugaheal® against indomethacin (IMN), a classical NSAID, induced gastric damage. Objective: Evaluation of the protective effect of Sugaheal® against indomethacin induced gastric ulceration. Methods: Indomethacin was orally administered in male Wistar rats to generate gastric ulcers. These rats were orally fed with aqueous solution of Sugaheal® prior to indomethacin administration. Oxidative stress biomarkers, activities of antioxidant enzymes, activities of mitochondrial enzymes and gastric tissue morphology were studied through histological analysis. Results: From those obtained data, it was seen that, indomethacin treatment altered all the above mentioned parameters whereas; Sugaheal® pre-treatment prevented those deleterious changes. Biochemical and histological data supported these findings. Conclusion: Hence it can be said that besides being a potent anti-diabetic drug, Sugaheal® also possess the potentiality to be used as an antiulcer drug against indomethacin induced gastric ulcer.

    Cite this article as : Nirajan Ghosal, Syed Benazir Firdaus, Shamreen Naaz, Sudeshna Paul, Arnab Kumar Ghosh, Aindrila Chattopadhyay, Vishwaraman Mohan, Prasad Thakurdesai, Sunil Bhaskaran, Sanjib Pattari, Debasish Bandyopadhyay, Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats, Journal of Pharmacy Research 2016,10(6),351-364.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Nirajan Ghosal1, Syed Benazir Firdaus1, 2, Shamreen Naaz1, Sudeshna Paul1, 3, Arnab Kumar Ghosh1, Aindrila Chattopadhyay3, Vishwaraman Mohan4, Prasad Thakurdesai4, Sunil Bhaskaran4, Sanjib Pattari5 and Debasish Bandyopadhyay1#

    Affiliation(s) Name:

    1Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92 APC Road, Kolkata 700 009, India
    2Department of Physiology, Govt. General College, Madpur, PaschimMedinipur, West Bengal
    3Department of Physiology, Vidyasagar College, 39, Sankar Ghosh Lane, Kolkata 700 009, India
    4CEO, Indus Biotech Pvt. Ltd. 1, Rahul Residency, Off. Salunke Vihar Road, Kondhwa, Pune, Maharashtra - 411 048, India.
    5RN Tagore International Institute of Cardiac Sciences, 124, Mukundapur, EM Bypass, Kolkata 700 099, India

    *Corresponding author.
    Dr. Debasish Bandyopadhyay
    Oxidative Stress and Free Radical Biology Laboratory,
    Department of Physiology, University of Calcutta
    University College of Science and Technology
    92 APC Road, Kolkata 700 009, India.

    Received on:25-03-2016; Revised on: 27-04-2016; Accepted on: 26-05-2016

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Nirajan Ghosal1, Syed Benazir Firdaus1, 2, Shamreen Naaz1, Sudeshna Paul1, 3, Arnab Kumar Ghosh1, Aindrila Chattopadhyay3, Vishwaraman Mohan4, Prasad Thakurdesai4, Sunil Bhaskaran4, Sanjib Pattari5 and Debasish Bandyopadhyay1#

    Title:Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
    Journal:Journal of Pharmacy Research
    Vol(issue):10(6)
    Year:2016
    Page No: (351-364)
  • Experimental Methods Keywords

    Methodology:Antioxidant, Gastric Ulcer,Oxidative stress biomarkers, activities of antioxidant enzymes, activities of mitochondrial enzymes , gastric tissue morphology
    Research Materials:Fenugreek 4-hydroxyisoleucine , trigonelline ,Sugaheal®

Keywords

Antioxidant Gastric Ulcer Indomethacin Non-Steroidal Anti Inflammatory Drugs (NSAIDS) Oxidative Stress Sugaheal®.

Our Services

Most Downloaded List