Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001285
Title: Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
Category: Pharmacology
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    Background: Sugaheal®, the 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) isolated from the seed of Trigonella foenum graecum (Linn.) is a well established antidiabetic drug. Several experiments have revealed that Sugaheal® also possesses good antioxidant characteristics. Gastric ulcer generally develops due to long term use of Non-Steroidal Anti Inflammatory Drugs (NSAIDs), consumed as pain killers. It is well established that oxidative stress and free radical mediated injury play a major role in generation of gastric ulcer. This influenced us to investigate the ameliorative role, if any, of Sugaheal® against indomethacin (IMN), a classical NSAID, induced gastric damage. Objective: Evaluation of the protective effect of Sugaheal® against indomethacin induced gastric ulceration. Methods: Indomethacin was orally administered in male Wistar rats to generate gastric ulcers. These rats were orally fed with aqueous solution of Sugaheal® prior to indomethacin administration. Oxidative stress biomarkers, activities of antioxidant enzymes, activities of mitochondrial enzymes and gastric tissue morphology were studied through histological analysis. Results: From those obtained data, it was seen that, indomethacin treatment altered all the above mentioned parameters whereas; Sugaheal® pre-treatment prevented those deleterious changes. Biochemical and histological data supported these findings. Conclusion: Hence it can be said that besides being a potent anti-diabetic drug, Sugaheal® also possess the potentiality to be used as an antiulcer drug against indomethacin induced gastric ulcer.

    Cite this article as : Nirajan Ghosal, Syed Benazir Firdaus, Shamreen Naaz, Sudeshna Paul, Arnab Kumar Ghosh, Aindrila Chattopadhyay, Vishwaraman Mohan, Prasad Thakurdesai, Sunil Bhaskaran, Sanjib Pattari, Debasish Bandyopadhyay, Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats, Journal of Pharmacy Research 2016,10(6),351-364.

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    Title:Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
    Journal:Journal of Pharmacy Research
    Vol(issue):10(6)
    Year:2016
    Page No: (351-364)
  • Experimental Methods Keywords

    Methodology:Antioxidant, Gastric Ulcer,Oxidative stress biomarkers, activities of antioxidant enzymes, activities of mitochondrial enzymes , gastric tissue morphology
    Research Materials:Fenugreek 4-hydroxyisoleucine , trigonelline ,Sugaheal®

Keywords

Antioxidant Gastric Ulcer Indomethacin Non-Steroidal Anti Inflammatory Drugs (NSAIDS) Oxidative Stress Sugaheal®.

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