Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001301
Title: Formulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan
Category: Pharmaceutics
Section: Research Article
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    Oral administration of bitter drugs, using novel solid dosage forms essentially require an acceptable degree of taste masking. Telmisartan is chosen as the model drug as it is bitter in taste and has poor water solubility and low bioavailability. Telmisartan is an orally active non peptide angiotensin II receptor antagonist belonging to BCS class II with an aqueous solubility of 9.9 µg/ml and log P of 7.7. One of the major formulation problems with this drug is the bitter taste which gives rise to patient compliance problems when it is given as conventional dosage forms. In the present study taste masking of telmisartan was achieved by preparing taste masked spherical agglomerates using a pH-sensitive polymer, Eudragit RS-100, and polymers like chitosan and carbopol. Taste assessment of these prepared agglomerates was done by both spectrophotometric taste evaluation technique and panel testing. Compressed tablets of taste masked agglomerates which rapidly disintegrated in the oral cavity were prepared using oxidized starch as directly compressible filler and sodium starch glycolate as a super-disintegrant. These were subsequently evaluated for various pharmacopoeial tests, drug release, and disintegration time in the oral cavity. Sensory taste evaluation was carried by panel testing in 20 healthy human volunteers. Results indicate successful formulation of taste masked oral fast disintegrating tablets which disintegrated in the oral cavity in about 30 s and possessed good taste.

    Cite this article as:Varinder Soni,Gagan Shah,Sandeep Rahar,Shaina Sharma, Formulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan,Journal of Pharmacy Research 2016,10(6),365-369.

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    Author(s) Name:

    Varinder Soni1*, Gagan Shah2, Sandeep Rahar3 andShaina Sharma2

    Affiliation(s) Name:

    1ShriVenkateshwara University, Gajroula, U.P,India.
    2Department of Pharmacognosy, Khalsa College of Pharmacy, Amritsar, Punjab,India
    3 Department of Pharmaceutical Chemistry, Khalsa College of Pharmacy, Amritsar, Punjab,India

    *Corresponding author.
    Varinder Soni
    ShriVenkateshwara University,
    Gajroula, U.P,India.


    Received on:12-03-2016; Revised on: 23-04-2016; Accepted on: 07-06-2016

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    Author:

    Varinder Soni1*, Gagan Shah2, Sandeep Rahar3 andShaina Sharma2

    Title:Formulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (June)
    Year:2016
    Page No: (365-369)
  • Experimental Methods Keywords

    Methodology:Fomulation and Evaluation,Spherical Agglomerates
    Research Materials:Telmisartan

Keywords

Eudragit RS-100 Chitosan Carbopol Spherical Agglomerates Telmisartan

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