Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-00001303
Title: Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats
Category: Pharmacognosy and Herbal Drugs related study
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    Background: Although Geranium seemannii Peyr. is widely used in Mexican traditional medicine, there is as yet no scientific study to explore the validity of this practice. Therefore, the aim of the present study was to evaluate the diuretic activity of the ethanolic extract of G. seemannii Peyr. to provide evidence about its effect. Methods: G. seemannii Peyr. was orally administered to adult male Wistar rats at 25 and 50 mg/kg, and its diuretic activity was evaluated and compared to the reference drug furosemide (20 mg/kg, administered intraperitoneally). Acute toxicity and lethality (LD50) of the extract were assessed. Results: Compared to control rats, there was significantly higher urinary output, as well as sodium, potassium and chloride ion excretion, in animals administered the ethanolic extract of G. seemannii Peyr. This effect was dose dependent, and there was no evidence of either acute toxicity or lethality with twice the maximum dose employed. Discussion: The diuretic activity of some plants has been attributed to the presence of flavonoids, and G. seemannii Peyr. has a relatively large concentration of ellagitannins. This could be responsible for the effect demonstrated herein, which was similar to that produced by the reference drug furosemide. The mechanism of action of furosemide is by inducing a loss of water through the inhibition of NaCl reabsorption. The results suggest that this receptor-mediated mechanism may account for the diuretic effect of G. seemannii Peyr. as well.

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    Author(s) Name:

    Jose´ Ramo´n Montejano-Rodrı´guez a,b, Georgina Almaguer-Vargas a, Juan Antonio Gayosso-De-Lucio a, Marı´a Esther Ocharan Herna´ndez b, Reyna Erika Moreno Martı´nez d, Marta Elena Herna´ndez Caballero b, J.J. Martı´n Torres-Valencia e, Jose´ Alfredo Sierra Ramı´rez b,c,*

    Affiliation(s) Name:

    a Instituto de Ciencias de la Salud, A´ rea Acade´mica de Farmacia, Universidad Auto´noma del Estado de Hidalgo, Pachuca de Soto, Hidalgo 42183, Mexico
    b Escuela superior de Medicina, Instituto Polite´cnico Nacional, Me´xico City 11340, Mexico
    c Instituto Nacional de Perinatologı´a Isidro Espinosa de los Reyes, Me´xico City 11000, Mexico
    d Departamento de Nefrologı´a y Metabolismo Mineral, Instituto Nacional de Nutricio´n Salvador Zubira´n. Me´xico City 14000, Mexico
    e Instituto de Ciencias Biolo´gicas, A´ rea Acade´mica de Quı´mica, Universidad Auto´noma del Estado de Hidalgo, Pachuca de Soto, Hidalgo 42083, Mexico

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    Author:

    Jose´ Ramo´n Montejano-Rodrı´guez a,b, Georgina Almaguer-Vargas a, Juan Antonio Gayosso-De-Lucio a, Marı´a Esther Ocharan Herna´ndez b, Reyna Erika Moreno Martı´nez d, Marta Elena Herna´ndez Caballero b, J.J. Martı´n Torres-Valencia e, Jose´ Alfredo Sierra Ramı´rez b,c,*

    Title:Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats
    Journal:Journal of Pharmacy Research
    Vol(issue):6(7)
    Year:2013
    Page No: (709-713)
  • Experimental Methods Keywords

    Methodology:Diuretic activity,
    Research Materials:Geranium seemannii Peyr.

Keywords

Diuretic activity Ethanolic extract Geranium seemannii Peyr.

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