Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001307
Title: Pilot study: Hypoglycemic and antiglycation activities of bitter melon (Momordica charantia L.) in type 2 diabetic patients
Category: Pharmacology
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    Background/Objectives: Bitter melon (Momordica charantia L., MC) has been used as a traditional remedy in diabetics due to its hypoglycemic activity. However, its antihyperglycemic effect and antiglycation activity have been demonstrated in vitro and in animal experiments, but not in a long-term clinical study. The aim of this study was to investigate the effect of bitter melon on long-term glycemic control and glycation status in type 2 diabetic patients. Methods: This study was a two-arm, parallel, randomized, double-blinded, placebocontrolled trial in which type 2 diabetic patients were randomized to continuously take either 6 g/day of MC dried-fruit pulp containing 6.26  0.28 mg of charantin (N = 19) or placebo (N = 19) for 16 weeks. Results: After 8 and 16 weeks of the treatment, the reduction of A1C frombaseline in the MC group was greater than that of the placebo group (0.25  0.12%, P = 0.042 and 0.31  0.15%, P = 0.044, respectively). In addition, the MC group showed a significant decline of total advanced glycation endproducts (AGEs) in serum after 16 weeks of the intervention. The mean difference between both groups was 8.22  3.58  103 AU/g protein (P = 0.028). The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum creatinine (Cr) did not change from baseline in each group and were not different between the two groups. None of participants experienced serious adverse events. Conclusions: It is possible that this herb is beneficial not only on glycemic control, but also on potential systemic complications of type 2 diabetes mellitus.

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    Author(s) Name:

    Wilai Trakoon-osot a,b, Uthai Sotanaphun c, Pariya Phanachet d,
    Supatra Porasuphatana e, Umaporn Udomsubpayakul b, Surat Komindr d,*

    Affiliation(s) Name:

    a Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand
    b Research Centre, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    c Department of Pharmacognosy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
    d Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    e Department of Pharmacogynosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand

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    Author:

    Wilai Trakoon-osot a,b, Uthai Sotanaphun c, Pariya Phanachet d,
    Supatra Porasuphatana e, Umaporn Udomsubpayakul b, Surat Komindr d,*

    Title:Pilot study: Hypoglycemic and antiglycation activities of bitter melon (Momordica charantia L.) in type 2 diabetic patients
    Journal:Journal of Pharmacy Research
    Vol(issue):6(8)
    Year:2013
    Page No: (859-864)
  • Experimental Methods Keywords

    Methodology:Diabetes mellitus, Hypoglycemic effect ,Advanced glycation endproducts
    Research Materials:Bitter melon, Momordica charantia

Keywords

Bitter melon Momordica charantia Diabetes mellitus Hypoglycemic effect Advanced glycation endproducts

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