Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001321
Title: Evaluation of in vitro anthelmintic activities of novel 1,2,3 - benzotriazole derivatives synthesized in ultrasonic and solvent free conditions
Category: Pharmaceutical Chemistry
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objectives: To determine anthelmintic activity of the synthesized novel 1,2,3- benzotriazole derivatives under ultrasonication in solvent free conditions. Methods: Newer“1-(1Hebenzo[d][1,2,3]triazole-1-carbonyl) derivatives” (5Ae5P) were synthesizedby using“1Hebenzo[d][1,2,3]triazole”(1)as the startingmaterialunder ultrasonicated and solvent -free conditions. The resulting products were isolated and characterized by melting points and spectral studies. All the products were assayed for anthelmintic activity against Pheretima posthuma using albendazole and mebendazole as reference compounds. Results: All the newer 1,2,3 e benzotriazole derivatives synthesized by ultrasound activation in solventefree condition were obtained in moderate to good yields in the range of 71e82%. The data interpretation of the spectral values with reference to standard values confirmed the structures of the synthesized compounds. Out of the sixteen synthesized derivatives, four compounds (5B, 5F, 5J and 5N) showed anthelmintic activity in dose-dependent manner giving shortest time of paralysis and death with different concentrations of the derivatives. Among these four derivatives, 5J showed superior activity. Conclusion: Out of the sixteen synthesized derivatives, four compounds (5B, 5F, 5J and 5N) containing p-nitrophenyl substituent attached to azo group of benzotriazole moieties exhibited equal or comparable anthelmintic activity with reference to albendazole. The superior activity of compound 5J might be due to attachment of additional p-nitrophenyl substituent to the cyano group.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    M.S. Sudhir a,c, R. Venkata Nadh b,*

    Affiliation(s) Name:

    a Department of Chemistry, Sri Subbaraya and Narayana College, Narasaraopet 522 601, Andhra Pradesh, India
    b School of Biotechnology, Vignan University, Vadlamudi, Guntur 522213, India

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    5 View More
  • How to Cite my Article.

    Author:

    M.S. Sudhir a,c, R. Venkata Nadh b,*

    Title:Evaluation of in vitro anthelmintic activities of novel 1,2,3 - benzotriazole derivatives synthesized in ultrasonic and solvent free conditions
    Journal:Journal of Pharmacy Research
    Vol(issue):7(1)
    Year:2013
    Page No: (47-52)
  • Experimental Methods Keywords

    Methodology:Anthelmintic activities,Solvent-free condition ,Ultrasonication
    Research Materials: 1,2,3- benzotriazoles, Pheretima posthuma

Keywords

Anthelmintic activities 1 2 3- benzotriazoles Pheretima posthuma Solvent-free condition Ultrasonication

Our Services

Most Downloaded List