Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001327
Title: Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants
Category: Pharmaceutics
Section: Research Article
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    Aim: Sildenafil citrate is the drug of choice for the treatment of erectile dysfunction. Bioavailability of Sildenafil citrate is 41% of orally administered dose. The objective of the present study was to develop fast dissolving tablets of Sildenafil citrate and improve its bioavailability, reduce the dosing frequency and thereby maximizing the therapeutic effect of the drug. Method: Sildenafil citrate fast dissolving tablets were prepared by wet granulation method using a combination of superdisintegrants, crospovidone and croscarmellose sodium along with various other excipients in order to confer a therapeutic enhancement on the drug and provide organoleptic characteristics in the final dosage form. Compatibility of the drug with the excipients was investigated by FTIR studies. Fourteen formulations (F1-F14) were prepared and subjected to various pre-compression and post-compression parameters such as average weight, weight variation, hardness, thickness, friability, wetting time, in-vitro disintegration time, drug content, and in-vitro drug release. Results: The results of all the formulations were examined after subjecting to various evaluation parameters. Among all the formulations, batch F12 produced promising results in terms of very fast disintegration in 34.11 seconds and dissolving 100.6% in 45 minutes. Hence it was considered as the optimized formulation. Stability study and kinetic modeling were carried out on the optimized formulation, F12. The in-vitro disintegration time and in-vitro drug release of the optimized formulation were compared with the innovator product. Conclusion: Sildenafil citrate fast dissolving tablets were found to be a promising one when compared to the innovator product as they increase the bioavailability, rapid onset of action, avert the problems of swallowing and improve the patient compliance.

    Cite this article as: Sandeep Kumar Reddy Adena, Kasi Viswanadh M, Ramya Krishna P, Anusha Induri, Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants,Journal of Pharmacy Research 2016,10(7),484-492.

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    Author(s) Name:

    Sandeep Kumar Reddy Adenaa,*, Kasi Viswanadh Mb, Ramya Krishna Pc, Anusha Indurid,

    Affiliation(s) Name:

    a,b,cAnnamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India.
    dSri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.

    *Corresponding author.
    Sandeep Kumar Reddy Adena
    Annamacharya College of Pharmacy,
    Rajampet, Andhra Pradesh, India


    Received on:05-11-2015; Revised on: 20-04-2016; Accepted on: 28-06-2016

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    Author:

    Sandeep Kumar Reddy Adenaa,*, Kasi Viswanadh Mb, Ramya Krishna Pc, Anusha Indurid,

    Title:Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (July)
    Year:2016
    Page No: (484-492)
  • Experimental Methods Keywords

    Methodology:Formulation , Evaluation,fast dissolving tablets; superdisintegrants; wet granulation method.
    Research Materials:Sildenafil citrate

Keywords

Sildenafil citrate; fast dissolving tablets; superdisintegrants; wet granulation method.

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