Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00001347
Title: Method development and statistical validation of UV spectrophotometric method for tolperisone hydrochloride in bulk and tablet dosage form
Category: Pharmaceutical Analysis
Section: Research Article
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    A simple, novel, sensitive, and specific spectrophotometric method was developed and validated for the determination of tolperisone hydrochloride in bulk and its dosage form. The drug was estimated by using water as solvent for this study, which is determined by spectrophotometrically at 260nm. The Beer-lamberts law was obeyed in a concentration range of 2-10μg /ml with correlation coefficient of 0.9992. The precision and accuracy of the developed method was confirmed by repeatability and recovery studies validated statistically. The LOD and LOQ of tolperisone hydrochloride were found to be 0.031μg/ml and 0.096μg/ml respectively. The percentage recovery study of the drug for the proposed method were found in the range of 99.76 - 101.39 % w/v for brand 1 and 99.87 – 101.16 % w/v for brand 2 . The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive.

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    Author(s) Name:

    I. Carolin Nimila1*, P.Balan1, N.Chiranjeevi1, V. Uma Maheswari1, S.Rajasekar1

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis,Faculty of Pharmacy,PRIST University,Thanjavur-614904.

    *Corresponding author.
    I. Carolin Nimila1
    Department of Pharmaceutical Analysis,
    Faculty of Pharmacy,
    PRIST University, Thanjavur-614904,
    Tamilnadu, India.


    Received on: 05-12-2010; Revised on: 14-01-2011; Accepted on:09-03-2011

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    Author:

    I. Carolin Nimila1*, P.Balan1, N.Chiranjeevi1, V. Uma Maheswari1, S.Rajasekar1

    Title:Method development and statistical validation of UV spectrophotometric method for tolperisone hydrochloride in bulk and tablet dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (May)
    Year:2011
    Page No: (1356-1357)
  • Experimental Methods Keywords

    Methodology:UV method development, validation
    Research Materials:Tolperisone HCL

Keywords

Tolperisone HCL UV method development validation

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