Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00001349
Title: Investigation of Hepatoprotective activity of Aerial Parts of Canna indica L. on carbon tetrachloride treated rats
Category: Pharmaceutical Analysis
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  • Abstract

    The hepatoprotective activity of methanol extract of aerial parts of Canna indica L. plant was evaluated against carbon tetrachloride induced hepatotoxicity. Extract at doses (100 and 200mg/kg) restored the levels of all serum parameters like SGPT, SGOT, TB which were elevated in CCl4 administrated rats. A 10% liver homogenate was used for estimation of catalase, GSH content, LPO level for in vivo antioxidant status of liver. All LPO, Reduced GSH, Catalase levels were observed normal in extract treated rats. Histopathology demonstrated profound necrosis, lymphocytic infiltration was observed in hepatic architecture of carbon tetrachloride rats which were found to obtain near normalcy in extract plus carbon tetrachloride administrated rats. This clearly suggests that methanol extract of aerial parts of Canna indica L. has liver protective effect against carbon tetrachloride induced hepatotoxicity.

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    Author(s) Name:

    Yadunath M. Joshi, Vilasrao J. Kadam, Yogita V. Patil, Prashant R. Kaldhone*

    Affiliation(s) Name:

    *Bharati Vidyapeeth’s College of Pharmacy, Sec – 8, CBD Belapur, Navi Mumbai 400614

    *Corresponding author.
    Mr.Prashant R. Kaldhone
    Bharati Vidyapeeth’s College of Pharmacy,
    CBD, Belapur, Navi Mumbai400614


    Received on: 25-07-2009; Accepted on:12-11-2009

     

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    Author:

    Yadunath M. Joshi, Vilasrao J. Kadam, Yogita V. Patil, Prashant R. Kaldhone*

    Title:Investigation of Hepatoprotective activity of Aerial Parts of Canna indica L. on carbon tetrachloride treated rats
    Journal:Journal of Pharmacy Research
    Vol(issue):2(12)
    Year:2009
    Page No: (1879-1882)
  • Experimental Methods Keywords

    Methodology:Hepatoprotective, Serum parameters, Antioxidant, Histopathology
    Research Materials:Canna indica L.

Keywords

Hepatoprotective Serum parameters Antioxidant Histopathology Canna indica L.

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