Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001351
Title: Recent advances in pharmacological activities of quinoxaline derivatives
Category: Pharmaceutical Chemistry
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  • Abstract

    Quinoxalines are well known and important nitrogen-containing heterocyclic compounds containing a ring complex made up of a benzene ring and a pyrazine ring. Diversely substituted quinoxalines and their derivatives embedded with variety of functional groups are important biological agents and a significant amount of research activity has been directed towards this class. Various methods have been worked out for their synthesis. Numerous quinoxaline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. They have several prominent pharmacological effects, such as antimicrobial, antimycobacterial, antifungal, antiviral, antiprotozoal, antimalarial, antiinflammatory,anticonvulsant, antidepressant and anticancer activities. They also possess some potent receptor selective biological activity like AMPA receptor antagonist activity. Quinoxaline 1,4-di-N-oxides seem to be the most frequently studied quinoxaline type compounds. As a result, a large number of such quinoxalines using different synthetic methods for their preparation have been described in the chemistry literature. The present review provides an insight view to quinoxaline synthesis and its biological activities along with the compilation of recent patents on quinoxaline.

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  • About the authors and Affiliations

    Author(s) Name:

    Asif Husain* and Diwakar Madhesia

    Affiliation(s) Name:

    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062

    *Corresponding author.
    Dr. Asif Husain
    Asst. Professor, Department of Pharmaceutical Chemistry,
    Faculty of Pharmacy, Jamia Hamdard (Hamdard University),
    Hamdard Nagar, New Delhi-110062.


    Received on: 04-10-2010; Revised on: 18-12-2010; Accepted on:16-02-2011

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    Author:

    Asif Husain* and Diwakar Madhesia

    Title:Recent advances in pharmacological activities of quinoxaline derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (March)
    Year:2011
    Page No: (924-929)
  • Experimental Methods Keywords

    Methodology: synthesis, biological activity, patents
    Research Materials:Quinoxalines, heterocycles

Keywords

Quinoxalines heterocycles synthesis biological activity patents

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